Circulating tumor cells in head and neck cancer: A review.
Circulating tumor cells in head and neck cancer: A review.
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DOI：
10.1016/j.wjorl.2016.05.003
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发表时间：
2016-06-01
期刊：
影响因子：
--
通讯作者：
Jatana, Kris R
中科院分区：
文献类型：
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作者：
McMullen, Kyle P;Chalmers, Jeffrey J;Jatana, Kris R
头颈部癌占所有癌症的3.5%，并且这些肿瘤中的绝大多数是鳞状细胞癌（HNSCC）。由于所有阶段的总存活率稳定在50%，因此继续有兴趣开发早期检测和疾病侵袭性的措施。循环肿瘤细胞（CTC）已被确定为头颈部鳞状细胞癌早期转移性疾病、治疗反应和监测的潜在标志物。本文就CTC检测技术、CTC技术的应用以及HNSCC患者的预后进行讨论。
Carcinoma of the head and neck represents 3.5% of all cancers, and the vast majority of these tumors are squamous cell carcinoma (HNSCC). With a stable overall survival rate of 50% among all stages, there is continued interested in developing measures for early detection and disease aggressiveness. Circulating tumor cells (CTCs) have been identified as a potential marker for early metastatic disease, response to treatment, and surveillance in head and neck squamous cell carcinoma. In this article, techniques of CTC detection, applications of CTC technology, and outcomes of HNSCC patients will be discussed.