Bone mineral density in adults with Down's syndrome
Bone mineral density in adults with Down's syndrome
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DOI：
10.1007/s003300050726
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发表时间：
1999-01-01
影响因子：
5.9
通讯作者：
Mandroukas, K
中科院分区：
文献类型：
--
作者：
Angelopoulou, N;Souftas, V;Mandroukas, K
该研究的目的是阐明唐氏综合症（DS）患者是否可能随着年龄的增长而增加骨质疏松症的风险，以及他们的早衰和骨骼异常。采用双能x线骨密度仪（DXA）测定22例家庭饲养成人（男性9例，女性13例，年龄分别为26.22+/-4.45岁和23.65+/-3.23岁）的骨密度。测量第二至第四腰椎的骨密度后前位投影，平均密度以克/平方厘米表示。将DS个体与27例同龄对照（男性12例，女性15例）（年龄分别为24.16+/-3.46岁和23.86+/-2.92岁）进行骨密度比较。结果显示，男性和女性退行性椎体滑移患者的腰椎骨密度均显著低于对照组（p < 0.001）。与雌性相比，雄性的骨密度低9%。导致这种疾病的因素可能主要是肌肉张力不足，久坐的生活方式和伴随的疾病，这些在综合征中经常观察到。未来的研究必须集中在骨代谢的生物化学，性腺，甲状腺和甲状旁腺功能的评估，以及额外的21号染色体的基因。
The objective of the study was to elucidate if individuals with Down's syndrome (DS) are likely to experience an increased risk of osteoporosis with advancing age, in addition to precocious aging and their skeletal anomalies. Bone mineral density (BMD) was measured in 22 home-reared adults (9 males and 13 females; age 26.22+/-4.45 and 23.65+/-3.23 years, respectively) by dual energy X-ray absorptiometry (DXA). The BMD of the second to fourth lumbar vertebrae was measured in posteroanterior projection and the mean density expressed as grams per square centimetre. The BMD of DS individuals was compared with 27 control subjects (12 males and 15 females) of the same age (age 24.16+/-3.46 and 23.86+/-2.92 years respectively). The results showed that the BMD of the lumbar spine in the males as well as in the females with DS was significantly lower than that in their control counter parts (p < 0.001). Comparing the DS males with the females, the BMD was lower in the males at a level of 9%. Factors that contribute to this disorder may be mainly the muscular hypotonia, the sedentary lifestyle and the accompanying diseases which frequent ly observed in the syndrome. Future studies must be focused on the biochemistry of bone metabolism, the evaluation of gonadal, thyroid and parathyroid function, and the genes of the extra chromosome 21.