Digoxin-like immunoreactive substance in patients with aneurysmal subarachnoid haemorrhage.
Digoxin-like immunoreactive substance in patients with aneurysmal subarachnoid haemorrhage.
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动脉瘤性蛛网膜下腔出血患者中的地高辛样免疫反应物质。
DOI：
10.1136/bmj.294.6574.729
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Gijn
中科院分区：
文献类型：
--
作者：
E. Wijdicks;M. Vermeulen;P. Brummelen;N. C. Boer;J. Gijn
通过放射免疫测定法测定了 25 名未接受地高辛治疗的动脉瘤性蛛网膜下腔出血患者血浆中的地高辛含量。加热血浆后，在 18 例病例中发现了与地高辛抗体发生交叉反应的内源性物质。这种物质的存在与血液总量以及额叶半球间裂中血液的存在显着相关，并且不能用高血压或水和钠的摄入来解释。地高辛阳性患者更常出现负钠平衡和容量不足，但这种关系并未达到统计学显着性。结论是，蛛网膜下腔出血可能导致下丘脑损伤，从而释放地高辛样利尿钠因子。
Digoxin was measured by radioimmunoassay in the plasma of 25 patients with aneurysmal subarachnoid haemorrhage who had not received digoxin treatment. After heating the plasma an endogenous substance cross reacting with antibodies to digoxin was identified in 18 cases. The presence of this substance was significantly related to the total amount of blood and to the presence of blood in the frontal interhemispheric fissure and could not be explained by hypertension or intake of water and sodium. A negative sodium balance and volume depletion occurred more often in patients who were positive for digoxin, but this relation did not reach statistical significance. It is concluded that a digoxin-like natriuretic factor is released in response to a subarachnoid haemorrhage, probably as a result of hypothalamic damage.