Changing partners at the dance: Variations in STAT concentrations for shaping cytokine function and immune responses to viral infections.
Changing partners at the dance: Variations in STAT concentrations for shaping cytokine function and immune responses to viral infections.
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DOI：
10.4161/jkst.23504
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
Biron CA
中科院分区：
文献类型：
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作者：
Kallal LE;Biron CA
细胞和分子成分的不同使用塑造了免疫反应，但对这些成分如何被调节以促进感染期间的防御和健康的理解仍然不完整。例如来自Janus激活的激酶信号转导和转录激活因子(JAK-STAT)细胞因子家族成员的信号。在受体刺激后，个别JAK-STAT细胞因子对特定的关键STAT分子有偏好，以导致特定的细胞反应。然而，这些细胞因子中的某些可以有条件地激活替代状态，并引发多效性和矛盾性效应。对基础和感染条件的研究揭示了不同细胞内STAT浓度下固有的和诱导的细胞差异，以控制细胞因子暴露的生物学后果。该系统可以比作在基于竞争和相对可获得性的舞蹈中交换舞伴，并建立了一个框架，用于理解在对感染的免疫反应进化过程中根据需要促进细胞因子亚组生物学功能的特定条件。
Differential use of cellular and molecular components shapes immune responses, but understanding of how these are regulated to promote defense and health during infections is still incomplete. Examples include signaling from members of the Janus activated kinase-signal transducer and activator of transcription (JAK-STAT) cytokine family. Following receptor stimulation, individual JAK-STAT cytokines have preferences for particular key STAT molecules to lead to specific cellular responses. Certain of these cytokines, however, can conditionally activate alternative STATs as well as elicit pleiotropic and paradoxical effects. Studies examining basal and infection conditions are revealing intrinsic and induced cellular differences in various intracellular STAT concentrations to control the biological consequences of cytokine exposure. The system can be likened to changing partners at a dance based on competition and relative availability, and sets a framework for understanding the particular conditions promoting subset biological functions of cytokines as needed during evolving immune responses to infections.