Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model.
Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model.
复制标题
抗帕金森病药物和半胱天冬酶抑制剂在帕金森病扁虫模型中的抑制作用。
DOI：
--
复制
发表时间：
2003
影响因子：
3.5
通讯作者：
Kenji Watanabe
中科院分区：
文献类型：
--
作者：
Y. Kitamura;M. Inden;H. Sanada;K. Takata;T. Taniguchi;S. Shimohama;H. Orii;M. Mochii;K. Agata;Kenji Watanabe
已知鱼藤酮和1-甲基-4-苯基吡啶离子（MPP（+），MPTP的代谢物）抑制线粒体复合物I，是脊椎动物如灵长类和啮齿类中帕金森病模型的有用工具。Planarian是一种无脊椎扁形虫，具有很高的再生潜力，多巴胺在其行为中起着关键作用。在本研究中，我们检查了一个克隆的真涡虫，GI株从三角洲。用鱼藤酮或MPTP处理的涡虫以浓度和时间依赖的方式进行自溶和个体死亡。此外，鱼藤酮或MPTP诱导的这些作用被几种抗帕金森病药物和半胱天冬酶抑制剂抑制。这些结果提示鱼藤酮或MPTP诱导的真涡虫多巴胺能系统的变性可能是通过激活半胱天冬酶样蛋白而介导的。
It has been known that rotenone and 1-methyl-4-phenylpyridinium ion (MPP(+), a metabolite of MPTP), which inhibit mitochondrial complex I, are useful tools for parkinsonian models in vertebrates such as primates and rodents. Planarian, an invertebrate flatworm, has a high potential for regeneration, and dopamine plays a key role in its behavior. In the present study, we examined a cloned planarian, the GI strain from Dugesia japonica. Planarians that were treated with rotenone or MPTP underwent autolysis and individual death in a concentration- and time-dependent manner. In addition, these effects induced by rotenone or MPTP were inhibited by several antiparkinsonian drugs and caspase inhibitors. These results suggest that the degeneration of planarian dopaminergic system induced by rotenone or MPTP may be mediated through caspase-like activation.
影响因子：
56.9
作者：
Masliah, E;Rockenstein, E;Mucke, L
通讯作者：
Mucke, L