Sympathovagal balance - A critical appraisal
Sympathovagal balance - A critical appraisal
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DOI：
10.1161/01.cir.96.9.3224
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发表时间：
1997-11-04
期刊：
影响因子：
37.8
通讯作者：
Eckberg, DL
中科院分区：
文献类型：
--
作者：
Eckberg, DL
考虑到自主神经系统对心血管健康的重要性，因此对测量人类交感神经和迷走神经流量作为可能告知生理和病理生理机制的工具存在并一直存在极大兴趣并不奇怪。帕加尼及其同事1提出了一个具有争议性的概念，即交感神经和迷走神经活动之间的瞬时平衡可以通过一个单一的数字来捕获，该数字是通过将以0.1 Hz为中心的RR间期频谱功率除以以较高频率（主要是呼吸频率）为中心的频谱功率来获得的。这个比例，或交感迷走神经平衡，已经被极大的热情所接受，因为它提供了新的可能性，通过使用完全非侵入性的，不引人注目的手段来理解动态的，至关重要的自主神经相互关系。3这种数学处理的广泛基础如下：（1）0.1 Hz RR间期主要由交感神经活动的波动介导;（2）高频RR间期节律几乎完全由迷走-心脏神经活动的波动介导;（3）生理干预往往引起交感神经和迷走神经流出的相互变化。交感迷走神经平衡，这些周期的比率，被用来反映相对的神经机制之间的平衡。本文综述了交感迷走神经平衡的生理基础。
Given the importance of the autonomic nervous system to cardiovascular health, it is not surprising that there is and has been great interest in measurements of human sympathetic and vagus nerve traffic as tools that might inform physiological and pathophysiological mechanisms. Pagani and coworkers 1 advanced the provocative notion that the instantaneous balance between sympathetic and vagal nerve activities can be captured by a single number, obtained by dividing RR-interval spectral power centered at≈ 0.1 Hz by spectral power centered at higher, primarily respiratory frequencies. This ratio, or sympathovagal balance, has been embraced with great enthusiasm 2 because it offers new possibilities for understanding dynamic, critically important autonomic interrelations in humans by the use of totally noninvasive, unobtrusive means. 3The broad bases for this mathematical treatment are as follows:(1) 0.1-Hz RR intervals are importantly mediated by fluctuations of sympathetic nerve activity;(2) higher-frequency RR-interval rhythms are mediated almost exclusively by fluctuations of vagal-cardiac nerve activity; and (3) physiological interventions tend to provoke reciprocal changes of sympathetic and vagal neural outflows. Sympathovagal balance, the ratio of these periodicities, is taken to reflect the balance between the opposing neural mechanisms. This review examines the physiological foundations of sympathovagal balance.