The molecular mechanism for nuclear transport and its application.
The molecular mechanism for nuclear transport and its application.
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DOI：
10.5115/acb.2017.50.2.77
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发表时间：
2017-06
影响因子：
1.1
通讯作者：
Oh SO
中科院分区：
文献类型：
--
作者：
Kim YH;Han ME;Oh SO
细胞质和核质之间的运输对于许多生理和病理生理过程（包括基因表达、信号转导和肿瘤发生）至关重要。因此，需要研究运输的分子机制，不仅可以了解细胞生理过程，还可以开发新的诊断和治疗靶点。将讨论通过核孔复合体进行核运输（输入和输出）以及影响核运输的四个重要因素（核孔蛋白、Ran、核转运蛋白和核定位信号/核输出信号）的最新研究进展。此外，还将回顾核转运的临床意义及其应用。这篇综述将为需要针对细胞核内的治疗药物的分子设计提供一些重要的见解。
Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.