Some thoughts on the relationship between vitamin A and cancer.
Some thoughts on the relationship between vitamin A and cancer.
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关于维生素A与癌症关系的一些思考。
DOI：
10.1007/978-1-4613-1835-4_28
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发表时间：
1986
影响因子：
--
通讯作者：
Olson,JA
中科院分区：
文献类型：
--
作者：
Olson,JA
类维生素A对多种肿瘤具有明显的预防和治疗作用。维生素A缺乏和维生素A过量，这是非常不同的状态，临床和代谢，应单独考虑相对于致癌作用。类维生素A和相关化合物的抗癌作用可能与其化学结构的关系比与维生素A的结构和功能的相似性更密切。类维生素A以多种方式作用于细胞和组织。虽然已经提出了许多有趣的想法来阐明它们的作用模式，但没有一个单一的假设足以解释它们的许多分子相互作用和反应。类维生素A和细胞之间的早期分子相互作用和随后的类维生素A在肿瘤和正常细胞中的代谢的调查可能有助于澄清他们的行动作为抗肿瘤剂。
Retinoids clearly show both prophylactic and therapeutic effects against many kinds of neoplasm. Vitamin A deficiency and vitamin A excess, which are very different states clinically and metabolically, should be separately considered relative to carcinogenesis. The anticancer effects of retinoids and related compounds may be more closely related to their chemical structure than to their similarity to the structure and function of vitamin A. Retinoids act on cells and tissues in a number of ways. Although many interesting ideas have been proposed to clarify their mode of action, no single hypothesis adequately explains their many molecular interactions and responses. Investigation of early molecular interactions between retinoids and cells and the subsequent metabolism of retinoids in neoplastic and normal cells may aid in the clarification of their action as antineoplastic agents.