Preparation and study of starch/ collagen/ polycaprolactone nanofiber scaffolds for bone tissue engineering using electrospinning technique
Preparation and study of starch/ collagen/ polycaprolactone nanofiber scaffolds for bone tissue engineering using electrospinning technique
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DOI：
10.33945/sami/ecc.2020.1.13
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Dizaj, Solmaz Maleki
中科院分区：
文献类型：
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作者：
Ghavimi, Mohammad Ali;Negandari, Ramin;Dizaj, Solmaz Maleki
骨组织工程近年来是一个快速发展的领域。它提出了一种新颖且巧妙的骨再生方法。目前工作的目的是通过静电纺丝方法生产基于淀粉/胶原/聚己内酯（PCL）生物材料的纳米纤维支架，用于骨组织工程目的。结果表明，所开发的结构具有良好的物理化学和互连特性，可考虑用于骨组织工程。表征结果表明，成功制备出具有单分散纳米尺寸（60 nm）、均匀网状形貌和负表面电荷（-13.5 mV）的纳米纤维。此外，所应用的方法可以用于使用其他聚合物材料制备纤维基结构。我们相信，通过掺入不同的材料来降低纤维的降解速度，可以与组织再生的速度相匹配。在这种情况下，制备的纳米纤维可以用作膜生物材料，例如引导骨再生（GBR）膜。
Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented method for bone regeneration. The aim of the current work is to produce nanofiber scaffolds based on starch/ collagen/ polycaprolactone (PCL) biomaterials by means of an electrospinning methodology for bone tissue engineering purposes. The results showed that the developed structures have good physicochemical and interconnected properties that could be considered for bone tissues engineering. The results from the characterization specified that the nanofibers were successfully prepared with monodispersed nanosized diameter (60 nm), uniform network shaped morphology and negative surface charge (-13.5 mV). Besides, the applied method can be set up to prepare fiber-based structures using other polymeric materials. We believe that by incorporating different materials to reduce the degradation rate of the fibers, it can be matched with the speed of tissue regeneration. In this case, the prepared nanofibers can be used as the membrane biomaterials, for example, guided bone regeneration (GBR) membrane.