Ethnic differences in resistance artery contractility of normotensive pregnant women
Ethnic differences in resistance artery contractility of normotensive pregnant women
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DOI：
10.1152/ajpheart.00919.2009
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发表时间：
2010-08-01
影响因子：
4.8
通讯作者：
van Montfrans, G. A.
中科院分区：
文献类型：
--
作者：
Brewster, L. M.;Taherzadeh, Z.;van Montfrans, G. A.
李建军，张建军，张建军，张建军，张建军，张建军。血压正常孕妇阻力动脉收缩力的种族差异。[J]中国生物医学工程学报，2016,31(2):431- 431。首次发表于2010年5月28日；doi: 10.1152 / ajpheart.00919.2009。黑人妇女在怀孕期间患高血压的风险更大，其致死性先兆子痫的发病率是白人妇女的4.5倍。因此，确定可能影响这种风险的因素非常重要。我们的研究小组先前提出，能量代谢中枢调节酶肌酸激酶（CK）的高活性可能会增加atp缓冲能力，导致血管收缩性增强，降低一氧化氮的生物利用度。因此，我们使用mulvanyi - halpern肌图评估了自定义的黑人和白人血压正常的孕妇分离的阻力动脉的微血管收缩特性。此外，用电子显微镜观察形态学。从剖宫产时捐献的网膜中获得的阻力大小的动脉（11名黑人妇女和20名白人妇女，平均年龄：34岁）进行了一系列研究，显示出相似的形态，但黑人[14.0 mN (1.8 SE)]与白人[8.9 mN (1.4 SE), P = 0.02]相比，黑人对去甲肾上腺素（10(-5)M）的最大收缩（10(-5)M）更大。此外，我们发现黑人女性在使用特异性CK抑制剂二硝基氟苯（10(-6)M）后比白人女性有更大的剩余收缩力[55% (6 SE)] [28% (4 SE), P = 0.001]，黑人女性在使用缓激肽（10(-7)M）后血管舒张减弱[103% (6 SE)]比白人女性[84% (5 SE), P = 0.023]，而对硝普钠（10(-4)M）和氨氯地平（10(-6)M）的反应相似。我们得出的结论是，与白人妇女相比，正常血压的怀孕黑人妇女表现出更大的动脉阻力收缩能力和更高的血管CK活性，同时一氧化氮合成减弱。这些在血压正常者中的发现可能暗示黑人在妊娠相关高血压疾病中有进一步的风险。
Brewster LM, Taherzadeh Z, Volger S, Clark JF, Rolf T, Wolf H, VanBavel E, van Montfrans GA. Ethnic differences in resistance artery contractility of normotensive pregnant women. Am J Physiol Heart Circ Physiol 299: H431-H436, 2010. First published May 28, 2010; doi:10.1152/ajpheart.00919.2009.-Black women are at a greater risk to develop hypertension during pregnancy, with a 4.5 times higher rate of fatal preeclampsia than white women. Therefore, it is important to identify factors that may affect this risk. Our group previously proposed that high activity of the central regulatory enzyme of energy metabolism, creatine kinase (CK), may increase ATP-buffering capacity and lead to enhanced vascular contractility and reduced nitric oxide bioavailability. Therefore, we assessed microvascular contractility characteristics in isolated resistance arteries from self-defined black and white normotensive pregnant women using a Mulvany-Halpern myograph. Additionally, morphology was assessed with electron microscopy. Resistance-sized arteries obtained from omentum donated during cesarean sections (11 black women and 20 white women, mean age: 34 yr) studied in series showed similar morphology but significantly greater maximum contractions to norepinephrine (10(-5) M) in blacks [14.0 mN (1.8 SE)] compared with whites [8.9 mN (1.4 SE), P = 0.02]. Furthermore, we found greater residual contractility after the specific CK inhibitor dinitrofluorobenzene (10(-6) M) in black women [55% (6 SE)] compared with white women [28% (4 SE), P = 0.001] and attenuated vasodilation after bradykinin (10(-7) M) in black women [103% (6 SE)] compared with white women [84% (5 SE), P = 0.023], whereas responses to sodium nitroprusside (10(-4) M) and amlodipine (10(-6) M) were similar. We conclude that compared with white women, normotensive pregnant black women display greater resistance artery contractility and evidence of higher vascular CK activity with attenuated nitric oxide synthesis. These findings in normotensives may imply that the black population is at risk for a further incline in pregnancy-related hypertensive disorders.