Melatonin Levels Decrease in the Umbilical Cord in Case of Intrauterine Growth Restriction.
Melatonin Levels Decrease in the Umbilical Cord in Case of Intrauterine Growth Restriction.
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DOI：
10.25122/jml-2020-0128
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发表时间：
2020-10
影响因子：
--
通讯作者：
Yuzko OM
中科院分区：
文献类型：
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作者：
Berbets AM;Barbe AM;Andriiets OA;Andriiets AV;Yuzko OM
宫内生长受限（IUGR）是围产儿发病和死亡的常见原因。此外，它往往并发胎儿窘迫。褪黑激素是一种抗氧化剂，它可以减轻组织缺氧引起的损伤。还已知促炎细胞因子和抗炎细胞因子的水平在怀孕期间发生变化。胎盘生长因子（PlGF）是胎盘血管生成的主要因子。我们的目的是调查是否褪黑素，细胞因子和PlGF在出生后的脐带血中的水平是不同的情况下，IUGR与正常胎儿相比。14例妊娠合并IUGR的妇女被纳入研究组。在妊娠第三个三个月，即妊娠30-36周，通过超声胎儿测量证实了IUGR的存在。所有患者均在妊娠37周后经阴道分娩。需要剖腹产、产钳或真空吸引胎儿的重度胎儿窘迫病例被排除在研究之外。我们发现，细胞因子的浓度没有显着差异组之间。此外，两组之间的分娩日间无显著差异。与正常妊娠相比，IUGR分娩时脐带血中褪黑激素和PlGF的浓度显着降低。我们认为，这一事实是由胎盘产生的褪黑激素和PlGF改变引起的。因此，IUGR时这两种因素对分娩时胎儿的保护作用降低。
Intrauterine growth restriction (IUGR) is a common reason for perinatal morbidity and mortality. Also, it is often complicated with fetal distress. Melatonin is widely known as an anti-oxidant agent, and it might decrease the damage of tissues caused by hypoxia. It is also known that levels of pro- and anti-inflammatory cytokines are changed during pregnancy. Placental growth factor (PlGF) is responsible for the angiogenesis in the placenta. We aimed to investigate whether the level of melatonin, cytokines, and PlGF in umbilical blood after birth is different in the case of IUGR compared to normal fetuses. Fourteen women whose pregnancies were complicated with IUGR were included in the study group. The presence of IUGR was confirmed by ultrasound fetometry in the third pregnancy trimester, 30-36 weeks of gestation. All patients delivered their children vaginally after 37 weeks of pregnancy. The cases of severe fetal distress that required a caesarian section, obstetrical forceps, or vacuum extraction of the fetus were excluded from the study. We found that the concentrations of cytokines did not differ significantly between the groups. Also, no significant difference in the daytime of delivery was found between the groups. The concentrations of melatonin and PlGF in the umbilical blood at labor were significantly lowered in the case of IUGR compared to normal pregnancies. This fact, as we consider, is caused by altered production of melatonin and PlGF by the placenta. Therefore, the protective action of these two factors for the fetus at labor is decreased in IUGR.