Mechano-insensitive nociceptors encode pain evoked by tonic pressure to human skin
Mechano-insensitive nociceptors encode pain evoked by tonic pressure to human skin
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DOI：
10.1016/s0306-4522(00)00189-5
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发表时间：
2000-01-01
期刊：
影响因子：
3.3
通讯作者：
Handwerker, HO
中科院分区：
文献类型：
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作者：
Schmidt, R;Schmelz, M;Handwerker, HO
记录人类受试者腓神经浅分支中的单个无髓鞘轴突（显微神经造影术），并使用先前描述的“标记技术”评估强直压力刺激（14 N，30 mm（2）; 120 a）期间的反应模式。有人发现，紧张性压力刺激引起的增强疼痛反应，这是由最初的机械不敏感（“沉默”）的C-单位放电相匹配，而机械和热响应的“多模态”C-伤害感受器显示出与刺激引起的感知，即强初始兴奋，随后适应的反应模式不兼容。研究了18种机械和热响应“多模态”C纤维和11种机械不敏感单元。前者有冯弗雷阈值
Single unmyelinated axons in the superficial branch of the peroneal nerve of human subjects were recorded (microneurography) and the response patterns during tonic pressure stimulation (14 N at 30 mm(2); 120 a) were assessed using the previously described "marking technique". It was found that tonic pressure stimuli induced augmenting pain responses which were matched by the discharges of initially mechano-insensitive ("silent") C-units, whereas mechano- and heat-responsive "polymodal" C-nociceptors showed a response pattern incompatible with the stimulus-induced perceptions, namely strong initial excitation, followed by adaptation. Eighteen mechano- and heat-responsive "polymodal" C-fibers and 11 mechano-insensitive units were studied. The former had von Frey thresholds