Differential control of sympathetic drive to the rat tail artery and kidney by medullary premotor cell groups
Differential control of sympathetic drive to the rat tail artery and kidney by medullary premotor cell groups
复制标题
髓质前运动细胞群对大鼠尾动脉和肾脏交感神经驱动的差异控制
DOI：
10.1016/s0006-8993(99)01568-1
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发表时间：
1999
期刊：
影响因子：
2.9
通讯作者：
R. McAllen
中科院分区：
文献类型：
--
作者：
J. Rathner;R. McAllen
记录麻醉大鼠的肾神经和腹侧尾动脉的交感神经活动，同时通过微量注射谷氨酸钠（1-15 nl，50 mM）激活三个交感前运动组的神经元，即延髓头腹外侧（RVLM）、延髓头腹内侧（RVMM）和中缝。 RVLM 激活使肾神经活动增加了 27±3%，但对尾部流出造成了微小且不一致的影响 (+15±10%)。中缝神经元刺激对肾神经影响很小（+8±3%），但强烈增加尾部交感神经单位活动（+125±28%）。 RVMM 神经元对任一流出几乎没有影响。这些结果表明不同的前运动细胞群具有不同的交感神经作用。
Sympathetic activity was recorded from the renal nerve and the ventral tail artery of anesthetized rats while neurons in three sympathetic premotor groups, the rostroventrolateral medulla (RVLM), rostroventromedial medulla (RVMM) and medullary raphe, were activated by microinjections of sodium glutamate (1–15 nl, 50 mM). RVLM activation increased renal nerve activity by 27±3% but caused small, inconsistent effects on the tail outflow (+15±10%). Raphe neuron stimulation had little effect on the renal nerve (+8±3%), but strongly increased tail sympathetic unit activity (+125±28%). RVMM neurons had little effect on either outflow. These results indicate that different premotor cell groups have different sympathetic actions.