Mechanical Changes in Fibrous Tissue Exposed to Non-Convergent Ultrasound
Mechanical Changes in Fibrous Tissue Exposed to Non-Convergent Ultrasound
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DOI：
10.1002/tee.23866
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发表时间：
2023-07-11
影响因子：
1
通讯作者：
Uchida，Satoshi
中科院分区：
文献类型：
--
作者：
Yagi，Ippei;Koike，Kazuki;Uchida，Satoshi
纤维化是一种涉及细胞外基质材料如胶原蛋白的异常积累的疾病，导致器官衰竭。这种类型的器官衰竭约占全球死亡人数的三分之一。然而，由于没有治疗这种疾病的药物，因此开发非侵入性治疗策略非常重要。在这项研究中，我们开发了一种使用非会聚超声辐射软化纤维化组织的方法，这是一种非热治疗。驻波中空化的产生导致纤维化组织的机械强度以辐照时间依赖性方式降低。照射后纤维组织的外观也发生了变化，可能是由于超声空化导致胶原纤维断裂。该方法具有治疗广泛纤维化组织的潜力。© 2023日本电气工程师协会和Wiley Periodicals LLC。
Fibrosis is a disease that involves an abnormal accumulation of extracellular matrix material such as collagen, leading to organ failure. This type of organ failure accounts for around one‐third of all deaths worldwide. However, since there are no drugs which are curative for this disease, the development of non‐invasive treatment strategies is important. In this study, we developed a method of softening fibrotic tissue using non‐converging ultrasound irradiation, a non‐thermal treatment. The generation of cavitation in a standing wave caused the mechanical strength of the fibrotic tissue to decrease in an irradiation time‐dependent manner. The appearance of the fibrous tissue also changed after irradiation, possibly due to the fracture of collagen fibers by ultrasonic cavitation. This method has the potential to treat a wide range of fibrotic tissues. © 2023 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC.