Relations between individual and neighborhood-based measures of socioeconomic position and bone lead concentrations among community-exposed men - The Normative Aging Study
Relations between individual and neighborhood-based measures of socioeconomic position and bone lead concentrations among community-exposed men - The Normative Aging Study
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DOI：
10.1093/oxfordjournals.aje.a009972
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发表时间：
1999-07-15
影响因子：
5
通讯作者：
Hu, H
中科院分区：
文献类型：
--
作者：
Elreedy, S;Krieger, N;Hu, H
为了研究铅暴露与社会经济地位的个人和地理区域指标之间的关系，作者测量了胫骨铅浓度，这是累积铅暴露的生物标志物，使用K x射线荧光对538名50-92岁的白人男性进行了横断面调查，这些男性在20世纪60年代参加了规范老龄化研究（波士顿，马萨诸塞州）。通过问卷调查收集个体危险因素、教育程度、职业、收入等数据。使用受试者在测量胫骨铅时的居住地址，作者通过将记录与1990年美国人口普查块组数据联系起来，获得了特定地理区域的教育、社会阶层和贫困程度。在控制年龄和吸烟累积的多元线性回归分析中，未高中毕业的男性胫骨铅浓度比大学毕业或等于4年的男性高10.39 μ g/g（95%可信区间（CI） 7.80-12.97）。在前男性（非高中毕业生）中，生活在受教育程度低的地区与生活在未受教育程度低的地区相比，胫骨铅水平增加9.28 μ g/g (95% CI 1.59-16.97)；在后一种男性（大学毕业生）中，居住地区教育程度没有差异（beta = 0.72, 95% CI -5.35 ~ 6.78）。作者得出结论，个人社会经济地位对累积铅暴露的影响受地理区域条件的影响。
To examine the association between lead exposure and both individual and geographic area indicators of socioeconomic position, the authors measured tibia lead concentration, a biomarker of cumulative lead exposure, using K x-ray fluorescence in a cross-sectional survey of 538 white males aged 50-92 years who were healthy when enrolled in the Normative Aging Study (Boston, Massachusetts) in the 1960s. Data on individual risk factors, education, occupation, and income were collected by questionnaire. Using subjects' residential addresses at the time of the tibia lead measurements, the authors obtained geographic area-specific measures of education, social class, and poverty by linking records to 1990 US Census block group data. In multivariate linear regression analysis controlling for age and cumulative smoking, tibia lead concentrations were 10.39 mu g/g (95% confidence interval (CI) 7.80-12.97) higher in men who did not graduate from high school than in men with greater than or equal to 4 years of college. Among the former men (non-high school graduates), living in an undereducated area was associated with a 9.28 mu g/g (95% CI 1.59-16.97) increase in tibia lead level compared with living in a non-undereducated area; among the latter men (college graduates), no difference existed by residential area education (beta = 0.72, 95% CI -5.35 to 6.78). The authors conclude that the influence of individual socioeconomic position on cumulative lead exposure is modified by geographic area conditions.