Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
复制标题
DOI：
10.1038/ng.2438
复制
发表时间：
2012-11-01
期刊：
影响因子：
30.8
通讯作者：
Tamari, Mayumi
中科院分区：
文献类型：
--
作者：
Hirota, Tomomitsu;Takahashi, Atsushi;Tamari, Mayumi
特应性皮炎是一种常见的炎症性皮肤病，由遗传和环境因素相互作用引起。根据全基因组关联研究 (GWAS) 和包含日本人群中总共 3,328 名特应性皮炎受试者和 14,992 名对照者的验证研究的数据，我们在此报告 8 个新的易感基因座：IL1RL1-IL18R1-IL18RAP（P 组合 = 8.36 x 10(-18)），即主要组织相容性复合物 (MHC) 区域(P = 8.38 x 10(-20))、OR10A3-NLRP10 (P = 1.54 x 10(-22))、GLB1 (P = 2.77 x 10(-16))、CCDC80 (P = 1.56 x 10(-19))、CARD11 (P = 7.83 x ZNF365 (P =我们还复制了先前在 GWAS 中报道的 FLG、C11orf30、TMEM232-SLC25A46、TNFRSF6B-ZGPAT、OVOL1、ACTL9 和 KIF3A-IL13 位点的关联。对欧洲和中国个体的研究以及对特应性皮炎的 GWAS 荟萃分析，这些发现促进了对特应性皮炎遗传基础的理解。
Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P-combined = 8.36 x 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 x 10(-20)), OR10A3-NLRP10 (P = 1.54 x 10(-22)), GLB1 (P = 2.77 x 10(-16)), CCDC80 (P = 1.56 x 10(-19)), CARD11 (P = 7.83 x ZNF365 (P = 5.85 x 10(-20)) and CYP24A1-PFDN4 (P = 1.65 x 10(-8)). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.