T-CELL AND MAST-CELL LINES RESPOND TO B-CELL STIMULATORY FACTOR-I
T-CELL AND MAST-CELL LINES RESPOND TO B-CELL STIMULATORY FACTOR-I
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DOI：
10.1073/pnas.83.15.5654
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发表时间：
1986-08-01
影响因子：
11.1
通讯作者：
PAUL, WE
中科院分区：
文献类型：
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作者：
MOSMANN, TR;BOND, MW;PAUL, WE
小鼠淋巴因子B细胞刺激因子1（BSF - 1）先前已就其对B淋巴细胞的作用进行了描述。我们现在提供的证据表明，BSF - 1还负责另外两种生物学活性。其中第一种是刺激或维持小鼠T细胞系的活化状态。第二种活性是在白细胞介素3共刺激下某些肥大细胞系增殖速率的增加。T细胞和肥大细胞的活性是由纯化的BSF - 1介导的，并且与来自某些T细胞系上清液的BSF - 1共同纯化。这些活性中的每一种都被单克隆抗 - BSF - 1抑制，但不被单克隆抗白细胞介素2抗体抑制。抗体抑制结果还表明，在我们所测试的活化T细胞上清液中，BSF - 1是这两种活性的主要或唯一来源。
The murine lymphokine B-cell stimulatory factor 1 (BSF-1) has been described previously in terms of its actions on B lymphocytes. We now provide evidence that BSF-1 is also responsible for two additional biological activities. The first of these is the stimulation or maintenance of a state of activation in mouse T-cell lines. The second activity is the increase in the proliferative rate of certain mast cell lines costimulated with interleukin 3. The T-cell and mast cell activities are mediated by purified BSF-1 and copurify with BSF-1 from supernatants of certain T-cell lines. Each of these activities is inhibited by monoclonal anti-BSF-1 but not by monoclonal anti-interleukin 2 antibody. The antibody inhibition results also indicate that BSF-1 is the major or only source of these two activities in the activated T-cell supernatants that we have tested.