Melatonin: A potential adjuvant therapy for septic myopathy
Melatonin: A potential adjuvant therapy for septic myopathy
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DOI：
10.1016/j.biopha.2022.114209
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发表时间：
2023-01-04
影响因子：
7.5
通讯作者：
Wang，Yuchang
中科院分区：
文献类型：
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作者：
Liu，Yukun;Wang，Dongfang;Wang，Yuchang
脓毒症肌病又称ICU获得性无力(ICU-AW)，是败血症患者特有的临床症状，主要表现为骨骼肌无力和肌肉萎缩，影响患者的呼吸和运动系统，降低生活质量，甚至威胁患者的生存。褪黑素是松果体分泌的一种荷尔蒙。以往的研究发现，褪黑素具有抗炎、清除自由基、抗氧化应激、自噬溶酶体调节、线粒体保护等多种生物学功能，对脓毒症相关的多器官功能障碍具有保护作用。鉴于先前的研究结果，我们认为褪黑素在败血症肌病骨骼肌萎缩的修复和再生中可能起到很好的调节作用。褪黑素作为一种非处方药，有可能成为临床试验的早期补充疗法。本文在总结前人研究成果的基础上，对褪黑素在脓毒症和骨骼肌衰竭中的作用进行了讨论和综述。
Septic myopathy, also known as ICU acquired weakness (ICU-AW), is a characteristic clinical symptom of patients with sepsis, mainly manifested as skeletal muscle weakness and muscular atrophy, which affects the respiratory and motor systems of patients, reduces the quality of life, and even threatens the survival of patients. Melatonin is one of the hormones secreted by the pineal gland. Previous studies have found that melatonin has anti-inflammatory, free radical scavenging, antioxidant stress, autophagic lysosome regulation, mitochondrial protection, and other multiple biological functions and plays a protective role in sepsis-related multiple organ dysfunction. Given the results of previous studies, we believe that melatonin may play an excellent regulatory role in the repair and regeneration of skeletal muscle atrophy in septic myopathy. Melatonin, as an over-the-counter drug, has the potential to be an early, complementary treatment for clinical trials. Based on previous research results, this article aims to critically discuss and review the effects of melatonin on sepsis and skeletal muscle depletion.