Trace metal ions in hair from frequent hair dyers in China and the associated effects on photo-oxidative damage
Trace metal ions in hair from frequent hair dyers in China and the associated effects on photo-oxidative damage
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中国经常染发的头发中的微量金属离子及其对光氧化损伤的影响
DOI：
10.1016/j.jphotobiol.2016.01.010
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发表时间：
2016
影响因子：
5.4
通讯作者：
Li Qiao
中科院分区：
文献类型：
--
作者：
Tang Ying;Dyer Jolon M.;Deb-Choudhury Santanu;Li Qiao
人的头发暴露在阳光下时会发生氧化修饰。在本研究中，从中国志愿者，包括经常染发剂和非染发剂的人的头发样品进行了分析的金属离子，如铁，铜，镁，铝，锌和铅。在UVA（315-400 nm）光老化过程中产生的羟基自由基进行了量化，并通过蛋白质组学和SEM分析表征了氧化损伤。得出的结论是，高水平的金属离子，特别是那些来自铁和铜，确定在染色的头发与羟基自由基的光生成增强和由此产生的光氧化损伤的头发。活性氧物质，包括羟基自由基，通过头发光敏剂的电子转移机制产生与头发蛋白质反应。对来自频繁染发者的头发样本进行蛋白质组学分析，无论年龄和性别如何，与未染色的样本相比，蛋白质氧化修饰水平几乎增加了1.6倍。因此，在光老化过程中，在染色头发样品的表面上观察到更明显的物理损伤，包括角质层鳞片的断裂和交联。这项工作旨在更好地了解金属离子在染色头发中的作用及其在光敏化头发蛋白中的可能作用。这项研究的结果预计将有助于改善染发化妆品和护发产品的发展。
Human hairs are subject to oxidative modification when exposed to sunlight. In the present study, samples of human hair from Chinese volunteers that included frequent hair dyers and non-dyers were analyzed for metal ions such as iron, copper, magnesium, aluminum, zinc and lead. The generation of hydroxyl radicals during UVA (315–400 nm) photoageing was quantified and oxidative damages characterized by proteomic and SEM analysis. It was concluded that high levels of metal ions, particularly those derived from iron and copper, identified in the dyed hairs are associated with enhanced photoformation of hydroxyl radicals and resultant photooxidative damage of the hair. Reactive oxygen species, including hydroxyl radicals, generated via an electron transfer mechanism with hair photosensitizers react with hair proteins. Proteomic analysis of hair samples from frequent hair dyers, regardless of age and gender, showed an almost 1.6 fold increase in the protein oxidative modification levels compared to the undyed samples. As a result, a more pronounced physical damage including fragmentation and cross-linkage of cuticle scales was observed on the surface of dyed hair samples during the photoageing. This work is aimed at better understanding the role of metal ions in dyed hairs and their possible role in photosensitizing hair proteins. The results from this study are anticipated to contribute to the improved development of hair coloring cosmetics and hair care products.