Notch signaling in the vasculature.
Notch signaling in the vasculature.
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DOI：
10.1016/s0070-2153(10)92009-7
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发表时间：
2010
影响因子：
--
通讯作者：
Gridley, Thomas
中科院分区：
文献类型：
--
作者：
Gridley, Thomas
Notch信号转导是一种进化上保守的细胞间信号转导机制，在脊椎动物血管发育和生理过程中发挥着多种作用。这些作用包括调节内皮细胞和血管平滑肌细胞的动静脉特化和分化、调节正常和病理性血管生成期间的血管发芽和分支以及血管平滑肌细胞的生理反应。Notch信号传导的缺陷也会导致遗传性血管疾病，如退行性血管疾病伴有皮质下白质脑病和白质脑病的常染色体显性脑动脉病（CADASIL）。本文综述了Notch信号通路在血管发育和生理过程中的作用。
Notch signaling is an evolutionarily-conserved, intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include the regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during normal and pathological angiogenesis, and the physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular diseases, such as the degenerative vascular disorder Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This review summarizes recent studies that highlight the multiple roles the Notch signaling pathway plays during vascular development and physiology.