Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets
复制标题
DOI：
10.1093/jb/mvh126
复制
发表时间：
2004-09-01
影响因子：
2.7
通讯作者：
Takigawa, M
中科院分区：
文献类型：
--
作者：
Kubota, S;Kawata, K;Takigawa, M
伤口愈合和组织再生通常通过凝血开始，然后形成纤维组织。在本研究中，我们发现人血小板中含有丰富的结缔组织生长因子（CTGF/CCN2），它随着凝血过程而释放。血小板中的CTGF/CCN2含量比动脉组织中高10倍。此外，经计算，单个血小板中的 CTGF/CCN2 含量比报道的任何其他生长因子高 20 倍以上。考虑到CTGF/CCN2促进血管生成、软骨再生、纤维化和血小板粘附，它现在可能被认为是血小板的主要功能成分之一。
Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of the major functional components of platelets.