Conformations of a charged vesicle interacting with an oppositely charged particle
Conformations of a charged vesicle interacting with an oppositely charged particle
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DOI：
10.1007/s10867-017-9471-6
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发表时间：
2018-03
影响因子：
1.8
通讯作者：
Hua Duan;Jianfeng Li;Hong-dong Zhang;F. Qiu;Yuliang Yang
中科院分区：
文献类型：
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作者：
Hua Duan;Jianfeng Li;Hong-dong Zhang;F. Qiu;Yuliang Yang
在理论上，胞吞和胞吐过程通常是用粒子-囊泡系统来研究的，但大多数都是电中性的。然而，带电粒子-囊泡系统更接近于真实的生物系统。因此，本文通过一系列二维动力学模拟系统地研究了带负电囊泡包裹带正电粒子的包裹行为。弹性弯曲能和静电能之间的竞争决定了囊泡的构型和电荷分布。据发现，只有在中等电荷浓度和小颗粒尺寸的囊泡可以完全吞没的颗粒。当电荷密度高时，囊泡和颗粒之间的相互作用意外地被带电膜的硬化效应和带电组分的有效运输冻结效应削弱。当粒子带强电荷时，观察到多层折叠构象。这些研究对了解生物系统中胞吞和胞吐过程的机制具有重要意义。
Endocytotic and exocytotic processes are usually studied using particle-vesicle systems in theory, but most of them are electroneutral. Nevertheless, charged particle-vesicle systems are much closer to real biological systems. Therefore, wrapping behaviors of a negatively charged vesicle wrapping a positively charged particle are systematically investigated by a series of 2D dynamical simulations in this article. The competition between the elastic bending energy and the electrostatic energy dictates the vesicle configuration and charge distribution. It is found that only for intermediate charge concentrations and small particle sizes a vesicle can completely engulf the particle. When the charge density is high, the interaction between vesicle and particle is unexpectedly weakened by both the hardening effect of the charged membrane and the effective-transportation-frozen effect of the charged components. When the particle is strongly charged, multi-layer folding conformations are observed. These studies may provide important insights into mechanism of endocytotic and exocytotic processes in biological systems.