The promises and challenges of human brain organoids as models of neuropsychiatric disease
The promises and challenges of human brain organoids as models of neuropsychiatric disease
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DOI：
10.1038/nm.4214
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发表时间：
2016-11-01
期刊：
影响因子：
82.9
通讯作者：
Arlotta, Paola
中科院分区：
文献类型：
--
作者：
Quadrato, Giorgia;Brown, Juliana;Arlotta, Paola
神经精神疾病，如自闭症谱系障碍（ASD），精神分裂症（SCZ）和双相情感障碍（BPD）具有重要的社会和医学意义，但这些疾病的复杂性和人类大脑发育和功能建模的挑战使得这些疾病难以进行实验研究。来源于人类多能干细胞的3D脑类器官的最新发展为研究这些高度多基因疾病的表型基础以及理解个体风险变异和复杂遗传背景对人类病理的贡献提供了一种有希望的方法。在此，我们讨论了人脑类器官作为神经精神疾病体外模型的优点、局限性和未来的应用。
Neuropsychiatric disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ) and bipolar disorder (BPD) are of great societal and medical importance, but the complexity of these diseases and the challenges of modeling the development and function of the human brain have made these disorders difficult to study experimentally. The recent development of 3D brain organoids derived from human pluripotent stem cells offers a promising approach for investigating the phenotypic underpinnings of these highly polygenic disorders and for understanding the contribution of individual risk variants and complex genetic background to human pathology. Here we discuss the advantages, limitations and future applications of human brain organoids as in vitro models of neuropsychiatric disease.