Genetic basis of continuous variation in the levels and modular inheritance of pigmentation in cichlid fishes.
Genetic basis of continuous variation in the levels and modular inheritance of pigmentation in cichlid fishes.
复制标题
DOI：
10.1111/mec.12900
复制
发表时间：
2014-11
影响因子：
4.9
通讯作者：
Parsons KJ
中科院分区：
文献类型：
--
作者：
Albertson RC;Powder KE;Hu Y;Coyle KP;Roberts RB;Parsons KJ
色素沉着类型和水平的变化是无数进化辐射的标志，生物学家长期以来一直着迷于促进和维持种群中颜色变化的因素。在这里，我们提供了对慈鲷鱼复杂和连续的颜色变化模式的遗传基础的见解，这提供了在自然和性选择的反应中进化出的巨大多样性的色素沉着模式。具体来说，我们将两个不同的慈鲷物种杂交，产生了一个F2定位种群，该种群在色素沉着水平和模式上表现出广泛的差异。我们的实验设计是稳健的，因为它结合了传统的数量性状位点（QTL）分析和群体基因组学，这使我们能够有效地从QTL区间移动到候选基因。总的来说，我们检测到41个QTL和13个上位相互作用，这些相互作用是这些鱼的鳍和侧翼上基于黑素细胞和黄素团的着色的基础。我们还发现了2个QTL和1个互作对这些颜色性状之间整合程度的变化。这一发现尤其值得注意，因为在色素沉着模式的复杂性方面，物种内部和物种之间都存在显著差异。虽然某些个体的特征是更统一的“综合”颜色模式，但其他个体在鳍和侧面的颜色“模块”分布方面表现出更多的自由度。我们的数据首次揭示了这种差异的遗传基础。最后，我们暗示pax3a作为沿慈鲷侧腹黄嘌呤为基础的颜色水平连续变化的中介。
Variation in pigmentation type and levels is a hallmark of myriad evolutionary radiations, and biologists have long been fascinated by the factors that promote and maintain variation in coloration across populations. Here, we provide insights into the genetic basis of complex and continuous patterns of colour variation in cichlid fishes, which offer a vast diversity of pigmentation patterns that have evolved in response to both natural and sexual selection. Specifically, we crossed two divergent cichlid species to generate an F2 mapping population that exhibited extensive variation in pigmentation levels and patterns. Our experimental design is robust in that it combines traditional quantitative trait locus (QTL) analysis with population genomics, which has allowed us to move efficiently from QTL interval to candidate gene. In total, we detected 41 QTL and 13 epistatic interactions that underlie melanocyte- and xanthophore-based coloration across the fins and flanks of these fishes. We also identified 2 QTL and 1 interaction for variation in the magnitude of integration among these colour traits. This finding in particular is notable as there are marked differences both within and between species with respect to the complexity of pigmentation patterns. While certain individuals are characterized by more uniform ‘integrated’ colour patterns, others exhibit many more degrees of freedom with respect to the distribution of colour ‘modules’ across the fins and flank. Our data reveal, for the first time, a genetic basis for this difference. Finally, we implicate pax3a as a mediator of continuous variation in the levels of xanthophore-based colour along the cichlid flank.
登录
查看更多内容
影响因子：
4.4
作者：
Chutimanitsakun Y;Nipper RW;Cuesta-Marcos A;Cistué L;Corey A;Filichkina T;Johnson EA;Hayes PM
通讯作者：
Hayes PM
影响因子：
7
作者：
Miller, Michael R.;Dunham, Joseph P.;Johnson, Eric A.
通讯作者：
Johnson, Eric A.
DOI：
10.1098/rspb.2010.2483
发表时间：
2011-08-07
影响因子：
4.7
作者：
Lehtonen, Topi K.;Meyer, Axel
通讯作者：
Meyer, Axel
影响因子：
2.7
作者：
Minchin, James E. N.;Hughes, Simon M.
通讯作者：
Hughes, Simon M.
影响因子：
3.3
作者：
Lee, BY;Lee, WJ;Kocher, TD
通讯作者：
Kocher, TD