New insights into IgG4-related disease: emerging new CD4+ T-cell subsets.
New insights into IgG4-related disease: emerging new CD4+ T-cell subsets.
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DOI：
10.1097/bor.0000000000000558
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发表时间：
2019-01
影响因子：
5.1
通讯作者：
Ichimiya S
中科院分区：
文献类型：
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作者：
Kamekura R;Takahashi H;Ichimiya S
最近获得了关于 IgG4 相关疾病 (IgG4-RD) 的新见解。更好地了解这种疾病的机制对于确定治疗靶点非常重要，这将有助于制定具体的治疗策略。在 IgG4-RD 受影响的组织中观察到活化的滤泡辅助 T (Tfh) 细胞的浸润。此类 Tfh 细胞比扁桃体 Tfh 细胞具有更大的帮助 B 细胞产生 IgG4 的能力。 IgG4-RD 患者的循环 PD-1hiCXCR5- 外周 T 辅助细胞 (Tph) 样细胞也有所增加。由于 Tph 样细胞表达高水平的趋化因子受体和颗粒酶 A，因此它们有能力浸润受影响的组织并发挥细胞毒功能。 Tph 样细胞也可以产生 CXCL13，因此 CXCR5+ Tfh 细胞和 B 细胞优先被募集以在该部位形成异位淋巴结构。在 IgG4-RD 病变中，Tph 细胞可能与 Tfh 细胞合作，引发炎症并维持持续的纤维炎症。最近在了解 IgG4-RD 发病机制方面取得了显着的进展。在这篇综述中，我们总结并讨论了 CD4+ T 细胞亚群在 IgG4-RD 中可能的病理作用。
New insights into IgG4-related disease (IgG4-RD) have recently been obtained. A better understanding of the mechanisms underlying this disease is important for identification of therapeutic targets, which will lead to the development of specific strategies for treatment. Infiltration of activated T follicular helper (Tfh) cells is observed in affected tissues of IgG4-RD. Such Tfh cells have a greater capacity than tonsillar Tfh cells to help B cells produce IgG4. Circulating PD-1hiCXCR5- peripheral T helper (Tph)-like cells are also increased in patients with IgG4-RD. Because Tph-like cells express high levels of chemokine receptors and granzyme A, they have the capacity to infiltrate affected tissues and exert a cytotoxic function. Tph-like cells can also produce CXCL13, and CXCR5+ Tfh cells and B cells are therefore preferentially recruited to form ectopic lymphoid structures in the sites. Tph cells may have a role to ignite inflammation and maintain persistent fibroinflammation in collaboration with Tfh cells in lesions of IgG4-RD. Recent advances in understanding the pathogenesis of IgG4-RD are remarkable. In this review, we summarize and discuss the possible pathologic role of CD4+ T-cell subsets in IgG4-RD.