Antioxidants, radiation and mutation as revealed by sperm abnormality in barn swallows from Chernobyl
Antioxidants, radiation and mutation as revealed by sperm abnormality in barn swallows from Chernobyl
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DOI：
10.1098/rspb.2004.2914
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发表时间：
2005-02-07
影响因子：
4.7
通讯作者：
Mousseau, TA
中科院分区：
文献类型：
--
作者：
Moller, AP;Surai, P;Mousseau, TA
降低类胡萝卜素、维生素A和E等抗氧化剂的水平会增加自由基引起的DNA损伤。暴露于辐射已被提议减少用于DNA修复的抗氧化剂的水平，这种减少可能是放射性污染地区突变水平增加的原因。我们测试这一假设使用现场测量的抗氧化剂的血液，肝脏和鸡蛋的谷仓燕子Hirundo rustica，而这些相关的突变水平所反映的频率异常精子。与未受污染的对照区相比，乌克兰切尔诺贝利的血液、肝脏和鸡蛋中的抗氧化剂水平降低，抗氧化剂水平与背景辐射水平呈负相关。异常精子的频率几乎是一个数量级高于在切尔诺贝利控制区，并在血液和肝脏中的抗氧化剂水平呈负相关。这与辐射与个人抗氧化剂水平之间存在直接联系的假设是一致的，表明由于抗氧化剂丰度的个体差异，个体之间的突变水平不同。
Reduced levels of antioxidants such as carotenoids and vitamins A and E can increase DNA damage caused by free radicals. Exposure to radiation has been proposed to reduce levels of antioxidants that are used for DNA repair and this reduction may be responsible for increased levels of mutation in radioactively contaminated areas. We test this hypothesis using field measures of antioxidants in blood, liver and eggs of the barn swallow Hirundo rustica while relating these to levels of mutation as reflected by the frequency of abnormal sperm. Antioxidant levels in blood, liver and eggs were reduced in Chernobyl, Ukraine, compared with an uncontaminated control area, and levels of antioxidants correlated negatively with levels of background radiation. The frequency of abnormal sperm was almost an order of magnitude higher in Chernobyl than in the control area and was negatively related to antioxidant levels in blood and liver. This is consistent with the hypothesis of a direct link between radiation and individual levels of antioxidants, suggesting that levels of mutation differ among individuals owing to individual differences in the abundance of antioxidants.