Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart
Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart
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DOI：
10.1291/hypres.30.439
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发表时间：
2007-05-01
影响因子：
5.4
通讯作者：
Sunagawa, Kenji
中科院分区：
文献类型：
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作者：
Tsutsui, Hiroyuki;Matsushima, Shouji;Sunagawa, Kenji
阻断肾素-血管紧张素系统可降低糖尿病患者的心血管发病率和死亡率。血管紧张素II(Ang II)在糖尿病心脏的结构和功能异常中起重要作用。观察血管紧张素Ⅱ1型受体阻滞剂(ARB)对链脲佐菌素(200 mg/kg)诱导的糖尿病(DM)雄性小鼠左室重构的影响。糖尿病小鼠给予坎地沙坦(1 mg/kg/d；DM+坎地沙坦，n=7)或赋形剂(DM+赋形剂，n=7)治疗8周。心率和主动脉血压在两组之间是相似的。糖尿病小鼠的正常收缩功能得以保留。相反，DM+组的舒张期功能受损，而DM+坎地沙坦组的舒张期功能得到改善，根据二尖瓣舒张期峰值速度减速时间(40.3±-0.3比37.3+/-0.5ms，p
Blockade of the renin-angiotensin system reduces cardiovascular morbidity and mortality in diabetic patients. Angiotensin II (Ang II) plays an important role in the structural and functional abnormalities of the diabetic heart. We investigated whether or not Ang II type 1 receptor blocker (ARB) could attenuate left ventricular (LV) remodeling in male mice with diabetes mellitus (DM) induced by the injection of streptozotocin (200 mg/kg, i.p.). Diabetic mice were treated with candesartan (1 mg/kg/day; DM+Candesartan, n=7) or vehicle (DM+Vehicle, n=7) for 8 weeks. Heart rate and aortic blood pressure were comparable between the groups. Normal systolic function was preserved in diabetic mice. In contrast, diastolic function was impaired in DM+Vehicle and was improved in DM+Candesartan, as assessed by the deceleration time of the peak velocity of transmitral diastolic flow (40.3 +/- 0.3 vs. 37.3 +/- 0.5 ms, p