Increased incidence of stroke in women with breast cancer
Increased incidence of stroke in women with breast cancer
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DOI：
10.1016/j.ejca.2004.11.013
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发表时间：
2005-02-01
影响因子：
8.4
通讯作者：
Blomqvist, C
中科院分区：
文献类型：
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作者：
Nilsson, G;Holmberg, L;Blomqvist, C
荟萃分析显示，接受放射治疗 (RT) 的乳腺癌女性患者出现过多的血管性死亡。对于患有乳腺癌的女性，锁骨上淋巴结放疗会给近端颈动脉带来大量辐射剂量。已知放疗会增加头颈癌颈动脉狭窄和缺血性中风的风险。确定了 25,171 名患有乳腺癌的女性的研究基础。研究基地和医院出院登记册之间的联系产生了 1766 名女性，她们在乳腺癌后被诊断出中风。将观察到的中风数量与背景人群中的预期数量进行比较。乳腺癌研究组中风的相对风险 (RR) 为 1.12（95% 置信区间 (CI) = 1.07-1.17）。风险增加仅限于脑梗塞亚型，RR = 1.12（95% CI = 1.05-1.19）。有乳腺癌病史的女性中风风险显着增加，具有统计学意义。这种风险是否与乳腺癌疾病本身有关或与任何治疗有关需要进一步研究。 (C) 2004 Elsevier Ltd. 保留所有权利。
Meta-analyses have shown an excess of vascular deaths in women with breast cancer given radiotherapy (RT). In women with breast cancer, RT to the supraclavicular lymph nodes gives a substantial radiation dose to the proximal carotid artery. RT is known to increase the risk of carotid stenosis and ischaemic stroke in head and neck cancer. A study base of 25,171 women with breast cancer was defined. A linkage between the study base and the Hospital Discharge Register yielded 1766 women who were diagnosed with a stroke after a breast cancer. The observed number of strokes was compared with the expected number in the background population. The Relative Risk (RR) of stroke in the study group with breast cancer was 1.12 (95% Confidence Interval (CI) = 1.07-1.17). The increased risk was confined to the subtype cerebral infarction, RR = 1.12 (95% CI = 1.05-1.19). A statistically significant increase in the risk of stroke was seen among women with a history of breast cancer. Whether this risk is associated with the breast cancer disease per se or related to any treatment requires further study. (C) 2004 Elsevier Ltd. All rights reserved.