The hedgehog signalling pathway in tumorigenesis and development
The hedgehog signalling pathway in tumorigenesis and development
复制标题
DOI：
10.1038/sj.onc.1203282
复制
发表时间：
1999-12-20
期刊：
影响因子：
8
通讯作者：
Bale, A
中科院分区：
文献类型：
--
作者：
Wicking, C;Smyth, I;Bale, A
刺猬信号通路负责一系列组织的胚胎模式，现在已知该通路的失调可导致几种肿瘤类型的形成。这种级联反应在细胞表面通过修补和平滑分子的相反作用进行调节，它们共同形成刺猬蛋白受体复合物。人类补丁基因失活是家族性和散发性基底细胞癌的原因，这一发现坚定地确立了hedgehog信号通路失调在肿瘤发生中的作用。该通路的其他关键成员也被证明参与肿瘤的形成，就像更多的远端下游目标的hedgehog信号传导一样。由于肿瘤的发生似乎是由刺猬应答基因的组成性激活引起的，因此在特定细胞类型中发现新的刺猬信号传导下游靶标可能会增加我们对肿瘤形成的分子过程的理解。
The hedgehog signalling pathway is responsible for the embryonic patterning of a range of tissues, and it is now known that dysregulation of this pathway can result in the formation of several tumour types. This cascade is regulated at the cell surface by the opposing actions of the patched and smoothened molecules which together form a receptor complex for hedgehog. The discovery that inactivation of the human patched gene is responsible for familial and sporadic forms of basal cell carcinoma firmly established a role for dysregulation of hedgehog signalling in tumorigenesis. Other key members of this pathway have also been shown to be involved in tumour formation, as have more distal downstream targets of hedgehog signalling. Since it appears that tumorigenesis results from constitutive activation of hedgehog responsive genes, the identification of novel downstream targets of hedgehog signalling in given cell types is likely to increase our understanding of the molecular processes underlying tumour formation.