High levels of Granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment
High levels of Granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment
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DOI：
10.1080/07357900701805678
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发表时间：
2008-06-01
影响因子：
2.4
通讯作者：
Gerbase-DeLima, Maria
中科院分区：
文献类型：
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作者：
Guzman, Valeska B.;Silva, Ismael D. C. G.;Gerbase-DeLima, Maria
本研究评估了宫颈癌中7种免疫应答基因的表达水平，并寻求与治疗应答的相关性。通过实时RTPCR评估治疗前肿瘤片段中的C、026、CTLA 4、ICOS、ICOSL、CD 80和CD 86以及颗粒酶B基因的表达水平。随访6个月，8例出现肿瘤，10例无瘤生存。在预后差的患者中表达水平较高的唯一基因（p = 0.03）是颗粒酶B。在充分把握度的前瞻性研究中进行进一步评价是必要的，以确认数据并将该观察结果转化为临床环境。
The present study assessed, in cervical carcinoma, expression levels of seven immune response genes and sought correlation to response to treatment. The expression levels of C,026, CTLA4, ICOS, ICOSL, CD80 and CD86 and granzyme B genes were assessed by real-time RTPCR in pre-treatment tumor fragments. During the six-month follow-up after treatment, 8 patients presented tumor and 10 survived free of tumor. The only gene whose expression levels, were higher in patients with poor outcome (p = 0.03) was granzyme B. Further evaluation, in adequately powered prospective studies is warranted to confirm the data and to translate this observation to the clinical setting.