Methylphenidate in hyperactive boys with comorbid tic disorder: II. Short-term behavioral effects in school settings.
Methylphenidate in hyperactive boys with comorbid tic disorder: II. Short-term behavioral effects in school settings.
复制标题
哌醋甲酯用于患有共病抽动障碍的多动男孩：II。
DOI：
10.1097/00004583-199205000-00012
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发表时间：
1992
影响因子：
13.3
通讯作者：
Sverd,J
中科院分区：
文献类型：
--
作者：
Gadow,KD;Nolan,EE;Sverd,J
在这项研究中，11名患有抽动障碍的青春期前多动男孩在双盲条件下接受安慰剂和三种剂量的哌醋甲酯(0.1、0.3和0.5 mg/kg)治疗2周。每个男孩在学校环境(教室座位活动、午餐间和操场)中被观察了大约20个小时。结果表明，哌醋甲酯有效地抑制了课堂上的过激/破坏性行为，以及食堂和操场上的身体攻击。哌醋甲酯还减少了教室和食堂的发声痉挛。所有运动抽动措施均未显示药物效应，但在0.3 mg/kg剂量时运动抽动的平均发生率最低。在手术确定的最小有效剂量下，只有一个男孩经历了运动性抽搐的加重。
In this study, 11 prepubertal hyperactive boys with tic disorder received placebo and three doses of methylphenidate (0.1, 0.3, and 0.5 mg/kg) for 2 weeks each, under double-blind conditions. Each boy was observed for approximately 20 hours in the school setting (classroom seatwork activities, lunchroom, and playground). Results showed that methylphenidate effectively suppressed hyperactive/disruptive behaviors in the classroom and physical aggression in the lunchroom and on the playground. Methylphenidate also reduced the occurrence of vocal tics in the classroom and the lunchroom. None of the motor tic measures revealed drug effects, but the lowest mean rate of motor tics occurred on the 0.3 mg/kg dose. On an operationally defined minimal effective dose, only one boy experienced motor tic exacerbation.