MESOLIMBIC AND MESOCORTICAL DOPAMINERGIC-NEURONS ARE NECESSARY FOR NORMAL EXPLORATORY-BEHAVIOR IN RATS
MESOLIMBIC AND MESOCORTICAL DOPAMINERGIC-NEURONS ARE NECESSARY FOR NORMAL EXPLORATORY-BEHAVIOR IN RATS
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DOI：
10.1016/0304-3940(80)90062-2
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
SMITH, GP
中科院分区：
文献类型：
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作者：
FINK, JS;SMITH, GP
在下丘脑前外侧注射6-羟基多巴胺（6-OHDA）产生的中脑边缘和中皮层多巴胺能神经元消融后，大鼠研究了一个新的物体less. Systemic管理的多巴胺（DA）激动剂阿扑吗啡增加这些DA-去神经大鼠的行为时，对象是新的，但不是当对象是熟悉的。匹莫齐特预处理可防止DA-去神经大鼠中阿扑吗啡产生的调查增加。中脑边缘和皮质中DA神经元，显然是必要的正常探索行为的大鼠。
After ablation of mesolimbic and mesocortical dopaminergic neurons produced by 6-hydroxydopamine (6-OHDA) injections in the anterolateral hypothalamus, rats investigate a novel object less. Systemic administration of the dopamine (DA) agonist apomorphine increases investigatory movements in these DA-denervated rats when the object is novel, but not when the object is familiar. Pimozide pretreatment prevents the increased investigation produced by apomorphine in DA-denervated rats. Mesolimbic and mesocortical DA neurons, apparently are necessary for normal exploratory behavior in the rat.