IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry.
IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry.
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DOI：
10.1146/annurev-immunol-101819-092536
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发表时间：
2021-04-26
影响因子：
29.7
通讯作者：
McGeachy MJ
中科院分区：
文献类型：
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作者：
Majumder S;McGeachy MJ
IL-17家族是一个进化古老的细胞因子家族，由6个成员组成（IL-17A-F）。IL-17家族细胞因子通过异二聚体受体发出信号，异二聚体受体包括IL-17RA亚基，该亚基在全身造血细胞和非造血细胞上广泛表达。家族成员IL-17A通常被称为IL-17，因其在牛皮癣等自身免疫性疾病中的促炎作用而受到最多关注。然而，IL-17与一系列可能具有令人惊讶的可变病理的疾病有关。本文将重点介绍IL-17在健康和疾病发病中的已知和新兴作用的最新进展。为了解释IL-17在各种疾病过程中的功能，首先考虑IL-17对健康的生理功能是有用的。然后，我们将讨论如何将这些有益的功能转向驱动慢性疾病的有害途径的致病性扩增。
The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A-F). IL-17 family cytokines signal through heterodimeric receptors that include the shared IL-17RA subunit which is widely expressed throughout the body on both hematopoietic and non-hematopoietic cells. The founding family member, IL-17A, is usually referred to as IL-17 and has received most attention for proinflammatory roles in autoimmune diseases like psoriasis. However, IL-17 is associated with a wide array of diseases with perhaps surprisingly variable pathologies. This review will focus on recent advances in the known and emerging roles of IL-17 during health and in disease pathogenesis. To decipher the functions of IL-17 in diverse disease processes it is useful to first consider the physiological functions that IL-17 contributes to health. We will then discuss how these beneficial functions can be diverted towards pathogenic amplification of deleterious pathways driving chronic disease.