Immobilization of polysaccharide derivatives onto silica gel - Facile synthesis of chiral packing materials by means of intermolecular polycondensation of triethoxysilyl groups
Immobilization of polysaccharide derivatives onto silica gel - Facile synthesis of chiral packing materials by means of intermolecular polycondensation of triethoxysilyl groups
复制标题
DOI：
10.1016/j.chroma.2007.04.054
复制
发表时间：
2007-07-20
影响因子：
4.1
通讯作者：
Okamoto, Yoshio
中科院分区：
文献类型：
--
作者：
Ikai, Tomoyuki;Yamamoto, Chiyo;Okamoto, Yoshio
用一种简单的方法合成了含有少量3-(三乙氧基硅基)丙基残基的纤维素和直链淀粉的3，5-二甲基苯基氨基甲酸酯，并通过三乙氧基硅基的分子间缩聚将其有效地固定在硅胶载体上。用高效液相色谱法对所制备的手性填充材料进行了表征。3-(三乙氧基硅基)丙基残基含量为1-2%的多糖衍生物具有较高的手性识别能力。固定化的CPM可以与含有氯仿和四氢呋喃的洗脱液一起使用，而这不能与常规包覆型CPM一起使用。通过使用这些洗脱剂，可以改善对许多外消旋体的手性识别。(C)2007 Elsevier B.V.保留所有权利。
The 3,5-dimethylphenylcarbamates of cellulose and amylose bearing a small amount of 3-(triethoxysilyl)propyl residues were synthesized by a simple process and efficiently immobilized onto a silica gel support by intermolecular polycondensation of the triethoxysilyl groups. The obtained chiral packing materials (CPMs) were evaluated by high-performance liquid chromatography. The polysaccharide derivatives containing about 1-2% of the 3-(triethoxysilyl)propyl residue were efficiently immobilized with a high chiral recognition. The immobilized CPMs could be used with the eluents containing chloroform and tetrahydrofuran, which cannot be used with the conventional coated-type CPMs. By using these eluents, the chiral recognitions for many racemates could be improved. (c) 2007 Elsevier B.V. All rights reserved.