Pediatric perfusion imaging using pulsed arterial spin labeling
Pediatric perfusion imaging using pulsed arterial spin labeling
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DOI：
10.1002/jmri.10372
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发表时间：
2003-10-01
影响因子：
4.4
通讯作者：
Detre, JA
中科院分区：
文献类型：
--
作者：
Wang, JJ;Licht, DJ;Detre, JA
目的：探讨1.5T脉冲动脉自旋标记(ASL)技术在儿童脑血流灌注成像中的可行性。材料与方法：对7例神经功能正常的儿童和5例健康成人进行ASL血流灌注成像。测量并比较两个年龄组的血流灌注图像的信噪比(SNR)、T1、M-0、动脉通过时间和ASL序列的时间波动。结果：在神经功能正常的儿童队列中，与成人相比，ASL灌注图像的信噪比增加了70%，绝对脑血流量增加了30%。ASL信噪比、T-1和M-0随年龄变化呈线性下降，ASL灌注图像序列的时间波动在两个年龄组之间没有显著差异。结论：ASL在儿童神经系统疾病的诊断中具有独特的优势，在安全性和图像质量方面具有独特的优势，是一种很有前途的儿童脑血流灌注成像工具。
Purpose: To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T.Materials and Methods: ASL perfusion imaging was carried out on seven neurologically normal children and five healthy adults. The signal-to-noise ratio (SNR) of the perfusion images along with T1, M-0, arterial transit time, and the temporal fluctuation of the ASL image series were measured and compared between the two age groups. In addition, ASL perfusion magnetic resonance (MR) was performed on three children with neurologic disorder.Results: In the cohort of neurologically normal children, a 70% increase in the SNR of the ASL perfusion images and a 30% increase in the absolute cerebral blood flow compared to the adult data were observed. The measures of ASL SNR, T-1, and M-0 were found to decrease linearly with age Transit time and temporal fluctuation of the ASL perfusion image series were not significantly different between the two age groups. The feasibility of ASL in the diagnosis of pediatric neurologic disease was also illustrated.Conclusion: ASL is a promising tool for pediatric perfusion imaging given the unique and reciprocal benefits in terms of safety and image quality.