Epidermal growth factor receptor expression is associated with poor outcome in cutaneous squamous cell carcinoma
Epidermal growth factor receptor expression is associated with poor outcome in cutaneous squamous cell carcinoma
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DOI：
10.1111/bjd.14936
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发表时间：
2017-05-01
影响因子：
10.3
通讯作者：
Roman-Curto, C.
中科院分区：
文献类型：
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作者：
Canueto, J.;Cardenoso, E.;Roman-Curto, C.
背景：皮肤鳞状细胞癌（CSCC）是仅次于基底细胞癌的人类第二大常见癌症，其发病率正在急剧上升。CSCC很少有问题，但鉴于其高频率，复杂病例的绝对数量也很高。鉴别预后不良的CSCCs有必要进行分子标记。关于表皮生长因子受体（EGFR）作为CSCC预后指标的作用存在争议。此外，近年来出现了EGFR靶向治疗，更好地了解EGFR在CSCC中的作用可能有助于一些患者预测预后和指导治疗管理。目的探讨EGFR在CSCC预后中的作用。方法对94例CSCC的临床和组织病理学特征进行分析，包括临床进展不佳的事件。用免疫组织化学、荧光原位杂交和定量聚合酶链反应分析EGFR的表达。结果85例（90%）检测到EGFR，过表达33例（35%），细胞质异常表达50例（53%）。原发性肿瘤中EGFR过表达与CSCC的淋巴结进展、肿瘤-淋巴结-转移分期进展和增殖（Ki-67染色）相关。在logistic回归模型中，EGFR过表达和分化程度差是定义CSCC淋巴结转移和进展的最强独立变量。结论EGFR过表达与CSCC的淋巴结转移和进展有关。
BackgroundCutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans after basal cell carcinoma, and its incidence is dramatically rising. CSCC is rarely problematic, but given its high frequency, the absolute number of complicated cases is also high. It is necessary to identify molecular markers in order to recognize those CSCCs with poor prognosis. There is controversy concerning the role of epidermal growth factor receptor (EGFR) as a marker of prognosis in CSCC. In addition, EGFR-targeted therapies have emerged in recent years and a better understanding of the role of EGFR in CSCC may be of help for some patients in predicting prognosis and guiding curative management.ObjectivesTo evaluate the role of EGFR as a prognostic factor in CSCC.MethodsWe evaluated clinical and histopathological features, including events of poor clinical evolution, in a series of 94 cases of CSCC. We also analysed EGFR expression by immunohistochemistry, fluorescent in situ hybridization and quantitative polymerase chain reaction.ResultsWe detected EGFR in 85 cases (90%), with overexpression in 33 cases (35%), and aberrant EGFR expression in the cytoplasm in 50 cases (53%). EGFR overexpression in the primary tumours was associated with lymph node progression, tumour-nodes-metastasis stage progression and proliferation (Ki-67 staining) in CSCC. EGFR overexpression and poor grade of differentiation were the strongest independent variables defining lymph node metastasis and progression in CSCC in a logistic regression model.ConclusionsWe demonstrate that EGFR overexpression has prognostic implications associated with lymph node metastasis and progression in CSCC.