Optimizing Cognitive Assessment Outcome Measures for Alzheimer's Disease by Matching Wordlist Memory Test Features to Scoring Methodology.
Optimizing Cognitive Assessment Outcome Measures for Alzheimer's Disease by Matching Wordlist Memory Test Features to Scoring Methodology.
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DOI：
10.3389/fdgth.2021.750549
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发表时间：
2021
影响因子：
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通讯作者：
Fortier D
中科院分区：
文献类型：
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作者：
Bock JR;Russell J;Hara J;Fortier D
认知评估与词表记忆测试是一种成本效益和非侵入性的方法，识别认知变化由于阿尔茨海默病和测量临床结果。然而，随着对认知变化的更精确和粒度测量的需求不断增加，特别是在阿尔茨海默病的早期或临床前阶段，传统的评分方法未能提供足够的准确性和信息。经过充分验证和广泛采用的单词列表记忆测试在许多方面都有所不同，包括列表长度，学习试验的数量，单词在试验中呈现的顺序，以及包含的语义类别，这些差异对认知有意义的影响。虽然许多简单的评分方法无法解释这些特征提供的信息，但已经做出了大量努力来开发评分方法，包括使用潜在模型，这些模型能够捕获这些信息用于临床前分化和预测认知变化。在这篇观点文章中，我们讨论了使用中的突出的单词表记忆测试，它们的功能，不同的评分方法如何失败或成功地捕捉这些功能提供的信息，以及对新兴的认知模型的建议，这些模型最佳地考虑了单词表记忆测试功能。将这些评分方法与具有适当特征的词表记忆测试相匹配，是获得精确测量细微认知变化的关键。
Cognitive assessment with wordlist memory tests is a cost-effective and non-invasive method of identifying cognitive changes due to Alzheimer's disease and measuring clinical outcomes. However, with a rising need for more precise and granular measures of cognitive changes, especially in earlier or preclinical stages of Alzheimer's disease, traditional scoring methods have failed to provide adequate accuracy and information. Well-validated and widely adopted wordlist memory tests vary in many ways, including list length, number of learning trials, order of word presentation across trials, and inclusion of semantic categories, and these differences meaningfully impact cognition. While many simple scoring methods fail to account for the information that these features provide, extensive effort has been made to develop scoring methodologies, including the use of latent models that enable capture of this information for preclinical differentiation and prediction of cognitive changes. In this perspective article, we discuss prominent wordlist memory tests in use, their features, how different scoring methods fail or successfully capture the information these features provide, and recommendations for emerging cognitive models that optimally account for wordlist memory test features. Matching the use of such scoring methods to wordlist memory tests with appropriate features is key to obtaining precise measurement of subtle cognitive changes.