Substance P receptor-dependent responses of leukocytes in pulmonary inflammation.
Substance P receptor-dependent responses of leukocytes in pulmonary inflammation.
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肺部炎症中白细胞 P 物质受体依赖性反应。
DOI：
10.1164/ajrccm/136.6_pt_2.s39
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Goetzl,EJ
中科院分区：
文献类型：
--
作者：
Payan,DG;Goetzl,EJ
肺部免疫反应可能部分由支配气道的神经纤维末端释放的神经肽介导和调节。支气管收缩、粘膜水肿和气道分泌物增加可能是由多种局部产生的神经肽介导的。神经肽直接或通过其他介质间接影响内皮细胞、平滑肌细胞、血管和白细胞的功能。在靠近肺平滑肌束的神经节丛中、沿着血管、以及进入支气管上皮和含有粘液腺腺泡的区域的神经投射中，多种有效神经肽的高含量提供了完全在获得这种生物效应所需的范围内的组织浓度。
Pulmonary immunologic responses may be mediated and modulated in part by neuropeptides released from the endings of nerve fibers that innervate the airways. Bronchoconstriction, mucosal edema, and increased airway secretions may be mediated by multiple locally generated neuropeptides. The neuropeptides affect directly and indirectly through other mediators the functions of endothelial cells, smooth muscle cells, blood vessels, and leukocytes. The high content of diverse potent neuropeptides in the ganglionated plexuses close to pulmonary smooth muscle bundles, along blood vessels, and in neural projections into the bronchial epithelium and regions containing acini of mucus glands provide tissue concentrations well within the range required to attain such biologic effects.