Association of MC4R gene variants with growth, fatness, carcass composition and meat and fat quality traits in heavy pigs.
Association of MC4R gene variants with growth, fatness, carcass composition and meat and fat quality traits in heavy pigs.
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DOI：
10.1016/j.meatsci.2005.10.016
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发表时间：
2006-05
期刊：
影响因子：
7.1
通讯作者：
C. Óvilo;A. Fernández;M. C. Rodríguez;M. Nieto;L. Silió
中科院分区：
文献类型：
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作者：
C. Óvilo;A. Fernández;M. C. Rodríguez;M. Nieto;L. Silió
黑素皮质素受体4 （MC4R）基因与人类和小鼠的摄食行为和体重的调节有关。位于该基因高度保守区域的错义突变（Asp298Asn）与不同猪品系的背膘深度、采食量和生长率明显相关。在这项工作中，从6头猪的商业杂交种样品中对该基因的完整编码区进行了测序，在709 （C/T）和1426 （G/ a）位置检测到两个多态性。最后一个与错义突变相对应，并在333只具有表型记录的动物和81个父母中的68个动物中进行了基因分型。在统计动物模型框架内进行了这些基因型与几种生产性能和品质性状的关联研究。结果证实了错意突变对生长和脂肪沉积性状（140天活重和背膘深度）的影响，并支持了对胴体组成（腰重和肩重）和脂肪和肉品质相关性状（脂肪酸谱、肌肉美能达L*、a*和Hocolour参数）的新影响。传播不平衡检验没有提供由于种群分层导致的虚假关联的证据。
The melanocortin receptor 4 (MC4R) gene is implicated in the regulation of feeding behaviour and body weight in humans and mice. A missense mutation (Asp298Asn) located in a highly conserved region of this gene has clearly been associated with backfat depth, feed intake and growth rate in different porcine lines. In this work the complete coding region of the gene was sequenced in samples from six pigs of a commercial hybrid line and two polymorphisms were detected at positions 709 (C/T) and 1426 (G/A). The last one corresponds to the missense mutation, and has been genotyped in 333 animals with phenotypic records and 68 out of their 81 parents. An association study of these genotypes with several performance and quality traits was performed within the statistical animal model framework. The results confirmed the effect of the missense mutation on growth and fat deposition traits (live weight at 140d and backfat depth), and supported new effects on carcass composition (loin and shoulder weights) and traits related to fat and meat quality (profile of fatty acids; muscle Minolta L*, a*and Hocolour parameters). A transmission-disequilibrium test provided no evidence of spurious association due to population stratification.