A fronto-parietal network is mediating improvement of motor function related to repetitive peripheral magnetic stimulation:: A PET-H2O15 study
A fronto-parietal network is mediating improvement of motor function related to repetitive peripheral magnetic stimulation:: A PET-H2O15 study
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DOI：
10.1016/j.neuroimage.2007.03.033
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发表时间：
2007-01-01
期刊：
影响因子：
5.7
通讯作者：
Bartenstein, Peter
中科院分区：
文献类型：
--
作者：
Struppler, Albrecht;Binkofski, Ferdinand;Bartenstein, Peter
重复性外周磁刺激（RPMS）是一种集中、无痛的刺激方法，通过末端运动分支的去极化引起肌肉收缩。近十年来对不同感觉运动整合障碍的临床实验研究表明，RPMS可用于脑卒中后运动功能的康复。据推测，这种治疗效果是基于rpms诱导的本体感觉流入中枢神经系统。利用皮质水平正电子发射断层扫描（PET）分析了RPMS对运动系统重组的调节作用。应用H2O15- PET测定了8例局灶性脑缺血后手臂瘫患者在上臂屈肌RPMS治疗前后的局部脑血流量（rCBF）。行为测量显示，在RPMS治疗后，受影响的手臂的手指运动的运动学和痉挛的减少显著改善。恢复与上后顶叶和运动前皮层（PM）区域的神经激活显著增加有关。RPMS治疗后顶叶-运动前网络的激活增加表明RPMS在皮层水平上具有显著的调节作用。这些结果强调了RPMS的积极治疗作用，并从中枢水平描述了其功能的生理基础。(C) 2007爱思唯尔公司版权所有。
Repetitive peripheral magnetic stimulation (RPMS) is a focused and painless stimulation method, in which muscle contractions are elicited by depolarization of the terminal motor branches. Clinical-experimental investigations on different disorders of sensorimotor integration in the last decade have shown that RPMS can be used for the rehabilitation of motor functions after stroke. It is supposed that this therapeutic effect is based on the RPMS-induced proprioceptive inflow to the CNS. To analyze the conditioning effects of RPMS on reorganization of the motor system on cortical level positron emission tomography (PET) is used. Regional cerebral blood flow (rCBF) has been measured using H2O15- PET in eight patients with arm paresis following focal cerebral ischemic infarction before and after treatment using RPMS on upper arm flexor muscles. Behavioral measures showed a significant improvement of kinematics of finger movements and a reduction of spasticity in the affected arm following RPMS treatment. The recovery was associated with significant increase of neural activation within the superior posterior parietal lobe and the premotor cortex (PM) areas. The increase of activation of the parieto-premotor network following RPMS treatment indicates a significant conditioning effect of RPMS on the cortical level. These results emphasize the positive therapeutic effect of RPMS and describe the physiological bases of its function on the central level. (C) 2007 Elsevier Inc. All rights reserved.