Gdnf signaling pathways within the mammalian spermatogonial stem cell niche
Gdnf signaling pathways within the mammalian spermatogonial stem cell niche
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DOI：
10.1016/j.mce.2008.04.012
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发表时间：
2008-06-25
影响因子：
4.1
通讯作者：
Hofmann, Marie-Claude
中科院分区：
文献类型：
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作者：
Hofmann, Marie-Claude
哺乳动物精子发生是一个复杂的过程，其中雄性生殖系干细胞发育并最终形成精子。精原干细胞，或称精原干细胞，存在于生精上皮的基底室。它们自我更新以维持整个生命中的干细胞库，或者它们分化产生大量生殖细胞。因此，成体睾丸中SSC自我更新和分化之间的平衡对于维持正常的精子发生和生育力至关重要。维持和自我更新受到来自周围微环境（称为精原干细胞龛）的外部信号的严格调节。通过物理支持SSC并为它们提供生长因子，支持细胞是生态位的主要组成部分。此外，将精原干细胞连接到生精小管之间的基底膜和睾丸间质细胞的细胞组分的粘附分子是生态位功能的重要调节剂。本文主要对支持细胞产生的维持精原干细胞自我更新的胶质细胞源性神经营养因子（glial cell line-derived neurotrophic factor，GDNF）及其下游信号通路进行综述。GDNF和其他信号通路，保持自我更新，以及新的SSC和塞尔托利细胞特异性转录因子的作用之间的相互作用，也进行了讨论。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Mammalian spermatogenesis is a complex process in which male germ-line stem cells develop to ultimately form spermatozoa. Spermatogonial stem cells, or SSCs, are found in the basal compartment of the seminiferous epithelium. They self-renew to maintain the pool of stem cells throughout life, or they differentiate to generate a large number of germ cells. A balance between SSC self-renewal and differentiation in the adult testis is therefore essential to maintain normal spermatogenesis and fertility. Maintenance and self-renewal are tightly regulated by extrinsic signals from the surrounding microenvironment, called the spermatogonial stem cell niche. By physically supporting the SSCs and providing them with growth factors, the Sertoli cell is the main component of the niche. In addition, adhesion molecules that connect the SSCs to the basement membrane and cellular components of the interstitium between the seminiferous tubules are important regulators of the niche function. This review mainly focuses on glial cell line-derived neurotrophic factor (Gdnf), which is produced by Sertoli cells to maintain SSCs self-renewal, and the downstream signaling pathways induced by this crucial growth factor. Interactions between Gdnf and other signaling pathways that maintain self-renewal, as well as the role of novel SSC- and Sertoli cell-specific transcription factors, are also discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.