Effects of a new dihydropyridine derivative, CV-4093.2HCl, on renal hemodynamics in spontaneously hypertensive rats.
Effects of a new dihydropyridine derivative, CV-4093.2HCl, on renal hemodynamics in spontaneously hypertensive rats.
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新型二氢吡啶衍生物 CV-4093.2HCl 对自发性高血压大鼠肾血流动力学的影响。
DOI：
10.1254/jjp.51.25
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
K. Hamajo
中科院分区：
文献类型：
--
作者：
Akinobu Nagaoka;M. Shibota;K. Hamajo
本文观察了新型钙拮抗剂CV-4093.2HCl对麻醉和清醒自发性高血压大鼠（SHR）肾血流动力学的影响。在麻醉大鼠中，CV-4093.2HCl（5和10 μ g/ kg，i. v.）显示出持久的消肿作用、扩张肾血管和增加肾血流量。CV-4093.2HCl的这些肾脏血流动力学作用比尼卡地平（5和10微克/公斤）更明显。此外，CV-4093.2HCl（10微克/kg，i. v.）抑制静脉注射去甲肾上腺素和血管紧张素II引起的肾血管收缩。CV-4093.2HCl的抑制作用比尼卡地平显著得多，但两种钙拮抗剂对血管活性物质引起的全身性升压反应的抑制作用几乎相同。此外，CV-4093.2HCl（1和3 mg/kg，p.o.）增加肾脏的血流量，但在清醒的SHR中，除小肠外的其他器官中的血流量没有增加。这些结果表明，CV-4093.2HCl对肾血管床（肾阻力血管）具有相对较高的亲和力，其对肾血流动力学的影响似乎有利于治疗高血压。
The effects of a new calcium antagonist, CV-4093.2HCl, on renal hemodynamics were examined in anesthetized and conscious spontaneously hypertensive rats (SHR). In the anesthetized rats, CV-4093.2HCl (5 and 10 micrograms/ kg, i.v.) showed a long-lasting hypotensive action, dilated renal vasculature, and increased renal blood flow. These renal hemodynamic actions of CV-4093.2HCl were more prominent than those of nicardipine (5 and 10 micrograms/kg). Moreover, CV-4093.2HCl (10 micrograms/kg, i.v.) inhibited renal vascular contractions induced by intravenous norepinephrine and angiotensin II. The inhibitory effect of CV-4093.2HCl was much more marked than that of nicardipine, although the inhibitory effects of both calcium antagonists on systemic pressor responses induced by the vasoactive substances were almost the same. In addition, CV-4093.2HCl (1 and 3 mg/kg, p.o.) increased blood flow in the kidneys but not in the other organs except for the small intestine in conscious SHR. These results suggest that CV-4093.2HCl has a relatively higher affinity for the renal vascular bed (renal resistance vessels), and its effect on renal hemodynamics seems to be beneficial for treating hypertension.