The Antidiabetic Action of Camel Milk in Experimental Type 2 Diabetes Mellitus: An Overview on the Changes in Incretin Hormones, Insulin Resistance, and Inflammatory Cytokines
The Antidiabetic Action of Camel Milk in Experimental Type 2 Diabetes Mellitus: An Overview on the Changes in Incretin Hormones, Insulin Resistance, and Inflammatory Cytokines
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DOI：
10.1055/s-0034-1368711
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发表时间：
2014-06-01
影响因子：
2.2
通讯作者：
Korish, A. A.
中科院分区：
文献类型：
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作者：
Korish, A. A.
民间医学故事认可骆驼奶（CMK）作为降血糖剂的能力，最近的研究已经在糖尿病患者和实验动物中证实了这一点。然而，CMK影响葡萄糖稳态的机制尚不清楚。本研究探讨了CMK治疗的糖尿病动物中葡萄糖稳态参数、肠促胰岛素激素和炎性细胞因子的变化。腹腔注射链脲佐菌素40 mg/kg/d，重复4次，建立2型糖尿病大鼠模型。给予骆驼奶治疗8周。研究胰高血糖素样肽-1（GLP-1）、葡萄糖依赖性促胰岛素肽（GIP）、葡萄糖耐量、空腹和葡萄糖刺激的胰岛素分泌、胰岛素抵抗（IR）、TNF-α、TGF-β 1、血脂、致动脉粥样硬化指数（AI）和体重的变化。与对照组相比，未处理的糖尿病动物显示高血糖症、HOMA-IR升高、高脂血症、AI升高、血清肠促胰岛素[GLP-1和GIP]、TNF-α和TGF-β 1水平升高以及体重减轻。对糖尿病动物的骆驼奶治疗导致空腹血糖水平显著降低、血脂降低、HOMA-IR降低、胰岛素分泌恢复、体重增加，并且在研究期间没有死亡。此外，CMK抑制糖尿病诱导的肠促胰岛素激素、TNF-α和TGF-β 1水平升高。增加葡萄糖刺激的胰岛素分泌，降低HOMA-IR，调节肠促胰岛素的分泌和/或作用，以及抑制作用是CMK抗糖尿病作用的预期机制，并表明CMK是一种有价值的辅助抗糖尿病治疗。
Folk medicine stories accredited the aptitude of camel milk (CMK) as a hypoglycemic agent and recent studies have confirmed this in the diabetic patients and experimental animals. However, the mechanism(s) by which CMK influences glucose homeostasis is yet unclear. The current study investigated the changes in the glucose homeostatic parameters, the incretin hormones, and the inflammatory cytokines in the CMK-treated diabetic animals. A model of type 2 diabetes mellitus was induced in rats by intraperitoneal injection of streptozotocin 40 mg/kg/day for 4 repeated doses. Camel milk treatment was administered for 8 weeks. The changes in glucagon like peptide-1 (GLP-1), glucose dependent insulinotropic peptide (GIP), glucose tolerance, fasting and glucose-stimulated insulin secretion, insulin resistance (IR), TNF-alpha, TGF-beta 1, lipid profile, atherogenic index (AI), and body weight were investigated. The untreated diabetic animals showed hyperglycemia, increased HOMA-IR, hyperlipidemia, elevated AI, high serum incretins [GLP-1 and GIP], TNF-alpha, and TGF-beta 1 levels and weight loss as compared with the control group. Camel milk treatment to the diabetic animals resulted in significant lowered fasting glucose level, hypolipidemia, decreased HOMA-IR, recovery of insulin secretion, weight gain, and no mortality during the study. Additionally, CMK inhibits the diabetes-induced elevation in incretin hormones, TNF-alpha and TGF-beta 1 levels. The increase in glucose-stimulated insulin secretion, decreased HOMA-IR, modulation of the secretion and/or the action of incretins, and the antiinflammatory effect are anticipated mechanisms to the antidiabetic effect of CMK and suggest it as a valuable adjuvant antidiabetic therapy.