I-E expression and susceptibility to parasite infection.
I-E expression and susceptibility to parasite infection.
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I-E 表达和对寄生虫感染的易感性。
DOI：
10.1016/0167-5699(87)90236-2
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
C. David
中科院分区：
文献类型：
--
作者：
D. L. Wassom;C. Krco;C. David
在大多数近交系小鼠中，抗原提呈细胞表达IA和IE抗原（II类主要组织相容性复合物抗原），这些抗原参与T细胞的抗原识别。在某些品系中，IE产物不表达或异常表达，但这些小鼠似乎免疫正常。在这篇文章中，Don Was~ om和他的同事讨论了在IE rJ背景下呈递的抗原引起抑制IA限制性T细胞增殖的反应的报道，这与他们自己的发现有关，即表达IE分子的小鼠比不表达IE的小鼠更容易受到某些线虫感染。这些肽为T细胞识别抗原提供了环境。大多数近交系小鼠在抗原呈递细胞表面表达两种I区产物IA和IE。然而，具有H-2的s、B、q或f单倍型的菌株不能表达IE产物1 ′ 2。B和s单倍型的小鼠在E1基因中具有缺失，f单倍型的小鼠主要合成大小异常的E1 mRNA，而q单倍型的小鼠似乎在R中具有缺陷。由于不能表达IE的小鼠在大多数方面是免疫学正常的，IE表达的进化意义仍然是个谜。然而，在几个实验系统中，研究人员发现，与IE分子相关的抗原呈递给T细胞会诱导一种反应，该反应抑制cJfJluLy IA限制性T细胞的-'-：'：'在体外增殖4，s。我们对这些报道很感兴趣，因为它们为我们的观察提供了一种机制解释，即表达IE分子的小鼠通常更容易感染infc：-
In most inbred strains of mice, antigen-presenting cells express IA and IE antigens (class II major histocompatibility complex antigens),,~ nd these antigens are involved in antigenrecognition by T cells. In some strains IE products are not expressed or aberrantly expressed, yet these mice seem to be immunologically normal.-In this article, Don Was~ om and his colleagues discuss reports that antigen presented in the context of IE rJroduces a response which suppresses IA restricted T-cell proliferation, in relation to their own findings that mice which do express IE molecules are more susceptible to certain nematode infections than mice which do not express IE.Genes within the I region of the mouse H-2 complex encode po! ypeptides which provide a context for recognition of antigen by T cells. Most inbred strains of mice express two I region products, IA and IE, on the surface of antigen-presenting cells. However, strains with the s, b, q or f haplotypes of H-2 fail to express the IE product 1'2. Mice of the b and s haplotypes bear a deletion in the E:, gene, f haplotype mice synthesize predominantly an E, mRNA of aberrant size, and mice of the q haplotype seem to have a defect in R. NA _processing or a problem with rnRNA stability, or both~ Since mice which fail to express IE are immunoiogically normal in most respects, the evolutionary significance of IE expression remains a mystery. However, in several experimental systems investigators discovered that antigen presente, l to T cells in association with the IE molecule induced a response which suppressed the-'-:':" of cJfJluLy IA-restricted T cells to proliferate in vitro 4, s. We were intrigued by these reports as they provide a mechanistic explanation for our observation that mice which express the IE molecule are generally more susceptible to infc:-
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旋毛虫：非 H-2 基因在小鼠抵抗原发感染中的作用。
影响因子：
2.1
作者：
Wassom,DL;Brooks,BO;Cypess,RH;David,CS
通讯作者：
David,CS
影响因子：
6.4
作者：
D. L. Wassom;D. Wakelin;Bradford O. Brooks;C. Krco;C. David
通讯作者：
D. L. Wassom;D. Wakelin;Bradford O. Brooks;C. Krco;C. David
对溶解的旋毛虫抗原的体外增殖反应的表征：1a抗原和Ly-1 T细胞的作用。
影响因子：
4.3
作者：
Krco,CJ;David,CS;Wassom,DL
通讯作者：
Wassom,DL
H-2 控制的剂量依赖性抑制反应，将成虫旋毛虫从小肠排出。
影响因子：
6.4
作者：
Wassom,DL;Dougherty,DA;Krco,CJ;David,CS
通讯作者：
David,CS
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Quintans,J;Suzuki,H;Sosman,JA;Shah,PD
通讯作者：
Shah,PD