Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology.
Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology.
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DOI：
10.3389/fimmu.2020.560381
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发表时间：
2020
影响因子：
7.3
通讯作者：
Martinón-Torres F
中科院分区：
文献类型：
--
作者：
Gómez-Rial J;Currás-Tuala MJ;Rivero-Calle I;Gómez-Carballa A;Cebey-López M;Rodríguez-Tenreiro C;Dacosta-Urbieta A;Rivero-Velasco C;Rodríguez-Núñez N;Trastoy-Pena R;Rodríguez-García J;Salas A;Martinón-Torres F
新的证据表明单核细胞在 COVID-19 免疫病理学中具有潜在作用。我们研究了 COVID-19 患者中单核细胞活化的两种可溶性标记物 sCD14 和 sCD163，目的是表征它们在单核细胞巨噬细胞疾病免疫病理学中的潜在作用。据我们所知，这是此类研究中的首次。前瞻性招募 59 名 SARS-Cov-2 阳性住院患者，根据 ICU 或非 ICU 入院要求进行分类，并通过 ELISA 分析 sCD14 和 sCD163 水平以及其他实验室参数，并与健康对照组进行比较。与对照组相比，无论是否入住 ICU 要求如何，COVID-19 患者的 sCD14 和 sCD163 水平均显着升高。我们发现非 ICU 患者组中 sCD14 水平与其他炎症标志物（特别是白细胞介素 6）之间存在显着相关性。 sCD163 与从入院到采样的时间呈中度正相关，与严重程度组无关。皮质激素治疗显示出对 sCD14 水平的干扰，而羟氯喹和托珠单抗则没有。在 SARS-Cov-2 感染中，单核细胞-巨噬细胞激活标记物增加，并与其他炎症标记物相关，与入院相关。这些数据表明单核细胞-巨噬细胞激活在 COVID-19 患者免疫病理学的发展中发挥着重要作用。
Emerging evidence indicates a potential role for monocytes in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in COVID-19 patients, with the aim of characterizing their potential role in monocyte-macrophage disease immunopathology. To the best of our knowledge, this is the first study of its kind. Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. sCD14 and sCD163 levels were significantly higher among COVID-19 patients, independently of ICU admission requirement, compared to the control group. We found a significant correlation between sCD14 levels and other inflammatory markers, particularly Interleukin-6, in the non-ICU patients group. sCD163 showed a moderate positive correlation with the time lapsed from admission to sampling, independently of severity group. Treatment with corticoids showed an interference with sCD14 levels, whereas hydroxychloroquine and tocilizumab did not. Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. These data suggest a preponderant role for monocyte-macrophage activation in the development of immunopathology of COVID-19 patients.
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