Mitochondrial pyruvate import and its effects on homeostasis.
Mitochondrial pyruvate import and its effects on homeostasis.
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DOI：
10.1016/j.ceb.2014.10.008
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发表时间：
2015-04
影响因子：
7.5
通讯作者：
Benoît Vanderperre;Tom Bender;Edmund R. S. Kunji;J. Martinou
中科院分区：
文献类型：
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作者：
Benoît Vanderperre;Tom Bender;Edmund R. S. Kunji;J. Martinou
亮点 两种内膜蛋白组成线粒体丙酮酸载体 (MPC) 复合物。MPC 活性的缺陷会扰乱细胞和全身代谢稳态。MPC 是治疗糖尿病、癌症和其他疾病的有前景的靶点。丙酮酸代谢在细胞稳态和能量产生中发挥着关键作用。丙酮酸是糖酵解的最终产物，要么在细胞质中分解代谢，要么进入线粒体促进氧化磷酸化。将丙酮酸输入线粒体需要线粒体内膜中的特定载体，即线粒体丙酮酸载体（MPC），其身份最近才被发现。在这里，我们报告了我们目前对 MPC 结构和功能的了解，并描述了 MPC 功能障碍如何参与各种病理学，包括 2 型糖尿病和癌症。
HighlightsTwo inner membrane proteins compose the mitochondrial pyruvate carrier (MPC) complex.Defects in MPC's activity perturb cellular and whole-body metabolic homeostasis.The MPC is a promising target for curing diabetes, cancer, and other diseases.Pyruvate metabolism plays a pivotal role in cell homeostasis and energy production. Pyruvate, the end product of glycolysis, is either catabolized in the cytosol, or enters into mitochondria to promote oxidative phosphorylation. The import of pyruvate into mitochondria requires a specific carrier in the inner mitochondrial membrane, the mitochondrial pyruvate carrier (MPC), whose identity was only recently discovered. Here we report our current knowledge of the structure and function of the MPC and we describe how dysfunction of the MPC could participate in various pathologies, including type 2 diabetes and cancer.