Reversible splenial lesion syndrome associated with SARS-CoV-2 infection in two children.
Reversible splenial lesion syndrome associated with SARS-CoV-2 infection in two children.
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DOI：
10.1016/j.braindev.2020.10.002
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发表时间：
2021-03
影响因子：
1.7
通讯作者：
Şevketoğlu E
中科院分区：
文献类型：
--
作者：
Bektaş G;Akçay N;Boydağ K;Şevketoğlu E
可逆性脾损伤综合征（RESLES）的特征是胼胝体脾脏出现暂时性损伤，与脑炎、癫痫发作、抗癫痫药物停药或代谢紊乱有关。在RESLES中，轻度脑炎/可逆性脾病变脑病（MERS）被定义为一种与病毒感染相关的独特临床放射学综合征。我们报告了两名患有多系统炎症综合征的儿童-与严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）相关的儿童在疾病过程中发生RESLES。脑病是主要的中枢神经系统症状。两例患儿均恢复迅速，脑磁共振成像显示脾病变在1周内完全消退。与SARS - CoV-2相关的RESLES患者脾脏病变的完全消退和脑病的快速恢复与MERS患者相似。
Reversible splenial lesion syndrome (RESLES) is characterized by a temporary lesion in the splenium of the corpus callosum, emerging related to encephalitis, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Among RESLES, mild encephalitis/encephalopathy with reversible splenial lesion (MERS) has been defined as a distinct clinicoradiologic syndrome associated with viral infections. We report two children with multisystem inflammatory syndrome-children related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed RESLES during the disease course. Encephalopathy was the main central nervous system symptom. Both of the children showed a rapid recovery, and brain magnetic resonance imaging revealed complete resolution of the splenial lesion within 1 week. The complete resolution of the splenial lesion and rapid recovery from encephalopathy in RESLES associated with SARS CoV-2 were similar to observed in MERS.
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