Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores
Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores
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DOI：
10.1021/nl402108g
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发表时间：
2013-10-01
期刊：
影响因子：
10.8
通讯作者：
Edel, Joshua B.
中科院分区：
文献类型：
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作者：
Cecchini, Michael P.;Wiener, Aeneas;Edel, Joshua B.
嵌入薄介电膜内的纳米孔传感器由于其检测从DNA和蛋白质到小分子和颗粒的大范围分析物的单分子灵敏度和相容性而获得了显著的兴趣。基于这一概念，我们利用金属Au固态膜易位和快速检测单个Au纳米粒子（NPs）功能化的拉曼光谱（SERRS）。我们表明，由于使用Au金属纳米孔表面和NP之间的表面增强共振等离子体耦合的589染料分子，当探测结合到NP表面的分析物分子时信号增强。虽然不是单个分子，但这种纳米孔感测方案受益于SERRS提供关于分析物的丰富振动信息的能力，从而改进了当前基于纳米孔的电学和光学检测技术。我们表明，完整的振动光谱的分析物可以检测到的光谱灵敏度和快速的时间分辨率为880 ps。
Nanopore sensors embedded within thin dielectric membranes have bee a gaining significant interest due to their single molecule sensitivity and compatibility of detecting a large range of analytes, from DNA and proteins, to small molecules and particles. Building on this concept we utilize a metallic Au solid-state membrane to translocate and rapidly detect single Au nanoparticles (NPs) functionalized Raman spectroscopy (SERRS). We show that, due to the with 589 dye molecules using surface enhanced resonance plasmonic coupling between the Au metallic nanopore surface and the NP, signal intensifies are enhanced when probing analyte molecules bound to the NP surface. Although not single molecule, this nanopore sensing scheme benefits from the ability of SERRS to provide rich vibrational information on the analyte, improving on current nanopore-based electrical and optical detection techniques. We show that the full vibrational spectrum of the analyte can be detected with ultrahigh spectral sensitivity and a rapid temporal resolution of 880 ps.