Autism Spectrum Disorder Is Associated With Autonomic Underarousal
Autism Spectrum Disorder Is Associated With Autonomic Underarousal
复制标题
DOI：
10.33549/physiolres.933528
复制
发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Tonhajzerova, I.
中科院分区：
文献类型：
--
作者：
Bujnakova, I.;Ondrejka, I.;Tonhajzerova, I.
自闭症谱系障碍（ASD）是一种严重的神经发育障碍，与自主神经失调有关。然而，导致自主神经异常的病理机制尚不清楚。本研究的目的是利用皮电活动（EDA）来评估同质组自闭症儿童基线时自主神经系统（ANS）的活动，作为交感神经活动和短期心率变异性（HRV）的指标，主要反映心脏迷走神经控制。对15名7-15岁的ASD男孩和15名健康同龄男孩进行了检查。在仰卧位静息期连续记录EDA和ECG。评价参数：HRV频谱分析低频段（LF-HRV: 0.04 ~ 0.15 Hz）和高频频段（HF-HRV: 0.15 ~ 0.4 Hz） EDA幅值（mu S）、RR间隔、谱功率、峰值频率和功率谱密度。与对照组相比，ASD组显著缩短了RR间隔（729 +/- 20 ms vs. 843 +/- 30 ms, p=0.005），降低了平均EDA (0.66 +/- 0.13 mu S vs. 1.66 +/- 0.42 mu S, p=0.033)，降低了HF-HRV的谱活度和功率谱密度(2.93 +/- 0.12 ms(2) vs. 3.38 +/- 0.10 ms(2), p= 0.01；4.12 + / - 0.10(2)女士/ Hz和4.56 + / - 0.11(2)女士/ Hz,分别为p = 0.008)。我们认为，与ASD相关的静息自主调节功能障碍可能是导致ASD潜在心血管并发症的重要病理机制。
Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder, associated with autonomic dysregulation. However, the pathomechanism leading to autonomic abnormalities is still unclear. The aim of this study was to assess autonomic nervous system (ANS) activity during baseline in homogenous group of autistic children using electrodermal activity (EDA), as an index of sympathetic activity and short-term heart rate variability (HRV) reflecting predominantly cardiac vagal control. Fifteen ASD boys and 15 healthy age-matched boys at the age of 7-15 years were examined. The continuous EDA and ECG were recorded during resting phase in a supine position. Evaluated parameters: EDA amplitude (mu S), RR interval, spectral power, peak frequency and power spectral density in low (LF-HRV: 0.04-0.15 Hz) and high-frequency (HF-HRV: 0.15-0.4 Hz) bands of HRV spectral analysis. In ASD group we found significantly shortened RR intervals (729 +/- 20 ms vs. 843 +/- 30 ms, p=0.005), lower mean EDA (0.66 +/- 0.13 mu S vs. 1.66 +/- 0.42 mu S, p=0.033), reduced spectral activity and power spectral density in HF-HRV compared to controls (2.93 +/- 0.12 ms(2) vs. 3.38 +/- 0.10 ms(2), p= 0.01; 4.12 +/- 0.10 ms(2)/Hz vs. 4.56 +/- 0.11 ms(2)/Hz, p= 0.008, respectively). We suggest that impairment in resting autonomic regulation associated with ASD could represent an important pathomechanism leading to potential cardiovascular complications in ASD.