Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo
Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo
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DOI：
10.1097/01.wcb.0000048519.34839.97
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发表时间：
2003-03-01
影响因子：
6.3
通讯作者：
Rothwell, NJ
中科院分区：
文献类型：
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作者：
Le Feuvre, RA;Brough, D;Rothwell, NJ
嘌呤能P2X（7）受体可能通过调节白细胞介素-1 β（IL-1 β）的加工和释放（IL-1 β是神经变性的关键介质）影响神经元细胞死亡。作者验证了这样的假设，即作用于P2X（7）受体的ATP有助于啮齿动物体内实验诱导的神经元死亡。P2X（7）受体的缺失（P2X（7）基因敲除小鼠）不影响暂时性脑缺血诱导的细胞死亡，而IL-1受体拮抗剂（IL-1RA）可降低暂时性脑缺血诱导的细胞死亡。用P2X拮抗剂治疗小鼠不影响缺血性或兴奋性毒性细胞死亡，表明P2X（7）受体不是实验诱导的神经元死亡的主要介质。
Purinergic P2X(7) receptors may affect neuronal cell death through their ability to regulate the processing and release of interleukin-1beta (IL-1beta), a key mediator in neurodegeneration. The authors tested the hypothesis that ATP, acting at P2X(7) receptors, contributes to experimentally induced neuronal death in rodents in vivo. Deletion of P2X(7) receptors (P2X(7) knockout mice) did not affect cell death induced by temporary cerebral ischemia, which was reduced by treatment with IL-1 receptor antagonist (IL-1RA). Treatment of mice with P2X antagonists did not affect ischemic or excitotoxic cell death, suggesting that P2X(7) receptors are not primary mediators of experimentally induced neuronal death.